Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Flubendiamide (682 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Tetraniliprole (544 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlf
Q-score: 0.375
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234 (Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlh
Q-score: 0.386
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr-c4657m/g4819e ca2+/atp/caffeine/cam1234 (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8y40
Q-score: 0.306
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr-i4657m/g4819e ca2+/atp/caffeine/cam1234/chl (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6m2w
Q-score: 0.309
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- Ryr1 (Complex from Oryctolagus cuniculus)
- Ryr1 ca2 /atp/caffeine/cam1234/chl (2 MDa, Complex)
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (539 kDa, Protein from Oryctolagus cuniculus)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Fkbp12.6 and cam1234 (Complex from Homo sapiens)
- Caffeine (194 Da, Ligand)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7cf9
Q-score: 0.232
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- Fkbp1b (Complex from Homo sapiens)
- Ryr1 (Complex from Oryctolagus cuniculus)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Ryanodine receptor 1,ryr1 (539 kDa, Protein from Oryctolagus cuniculus)
- Ryr1 ca2+/chl (2 MDa, Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)