Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Structure of PKA phosphorylated human RyR2-R420Q in the primed state
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8uxc
Q-score: 0.466
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8uxe
Q-score: 0.391
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ DOI: doi:10.1038/s41467-024-51791-y Pubmed: 39278969 ]
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420q and calstabin-2 in the presence of arm210 (Complex)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the primed state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uxf
Q-score: 0.454
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8uxg
Q-score: 0.434
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8uxh
Q-score: 0.366
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8uxi
Q-score: 0.39
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8uxl
Q-score: 0.417
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Calmodulin (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8uxm
Q-score: 0.381
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Calmodulin (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
Structure of human RyR2-S2808D in the subprimed state
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8uq2
Q-score: 0.443
Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR
Nat Commun (2024) 15 pp. 8080-8080 [ Pubmed: 39278969 DOI: doi:10.1038/s41467-024-51791-y ]
- Complex of ryr2-s2808d and calstabin-2 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)