Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Flubendiamide (682 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Tetraniliprole (544 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlf
Q-score: 0.375
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234 (Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlh
Q-score: 0.386
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr-c4657m/g4819e ca2+/atp/caffeine/cam1234 (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8y40
Q-score: 0.306
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr-i4657m/g4819e ca2+/atp/caffeine/cam1234/chl (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of recombinant RyR2 mutant K4593A (EGTA dataset)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vmr
Q-score: 0.362
Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H
Nat Commun (2022) 13 pp. 2821-2821 [ Pubmed: 35595836 DOI: doi:10.1038/s41467-022-30429-x ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (18 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (533 kDa, Protein from Mus musculus)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Fkbp1b (Complex)
- Recombinant ryr2 mutant k4593a in the presence of egta (Complex from Mus musculus)
Structure of recombinant RyR2 (EGTA dataset, class 1 2, closed state)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vml
Q-score: 0.413
Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H
Nat Commun (2022) 13 pp. 2821-2821 [ Pubmed: 35595836 DOI: doi:10.1038/s41467-022-30429-x ]
Structure of recombinant RyR2 (Ca2+ dataset, class 1, open state)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7vmo
Q-score: 0.379
Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H
Nat Commun (2022) 13 pp. 2821-2821 [ Pubmed: 35595836 DOI: doi:10.1038/s41467-022-30429-x ]
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7t64
Q-score: 0.306
Iyer KA, Hu Y, Klose T, Murayama T, Samso M
PNAS (2022) 119 pp. e2122140119-e2122140119 [ Pubmed: 35867837 DOI: doi:10.1073/pnas.2122140119 ]
- Zinc ion (65 Da, Ligand)
- Rabbit ryr1 disease mutant y523s in complex with fkbp12.6 embedded in lipidic nanodisc in the closed state (2 MDa, Complex)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 7t65
Q-score: 0.348
Iyer KA, Hu Y, Klose T, Murayama T, Samso M
PNAS (2022) 119 pp. e2122140119-e2122140119 [ DOI: doi:10.1073/pnas.2122140119 Pubmed: 35867837 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Rabbit ryr1 disease mutant y523s in complex with fkbp12.6 embedded in lipidic nanodisc in the open state (2 MDa, Complex)