Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6m2w
Q-score: 0.309
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Fkbp12.6 and cam1234 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1 ca2 /atp/caffeine/cam1234/chl (2 MDa, Complex)
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (539 kDa, Protein from Oryctolagus cuniculus)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7cf9
Q-score: 0.232
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- Ryanodine receptor 1,ryr1 (539 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Fkbp1b (Complex from Homo sapiens)
- Ryr1 ca2+/chl (2 MDa, Complex)
Structure of RyR2 (F/A/C/Ca2+ dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6ji0
Q-score: 0.322
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/apoCaM dataset)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6ji8
Q-score: 0.384
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Ryr2 in complex with fkbp12.6 and apo-calmodulin (Complex from Sus scrofa)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6jii
Q-score: 0.319
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
- Ryr2 in complex with fkbp12.6 and apo-calmodulin-mimicking mutant (Complex from Sus scrofa)
Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6jiu
Q-score: 0.303
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Zinc ion (65 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 in complex with fkbp12.6 and ca2+-loaded calmodulin at low ca2+ concentrations (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6jiy
Q-score: 0.375
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr2 in complex with fkbp12.6 and ca2+-loaded calmodulin at high ca2+ concentrations (Complex from Sus scrofa)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (*F/A/C/L-Ca2+ dataset)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6jrr
Q-score: 0.39
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 in complex with fkbp12.6 (Complex from Sus scrofa)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6jrs
Q-score: 0.421
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N
Nature (2019) 572 pp. 347-351 [ Pubmed: 31278385 DOI: doi:10.1038/s41586-019-1377-y ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Ryr2 in complex with fkbp12.6 and calmodulin (Complex from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr2 (564 kDa, Protein from Sus scrofa)
Structural basis for gating and activation of RyR1 (30 uM Ca2+ dataset, all particles)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5t15
Q-score: 0.398
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr1-cs2 complex (Complex)