Structure of human GlcNAc-1-phosphotransferase complexed with the donor substrate UDP-GlcNAc
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bgf
Q-score: 0.577
Li H, Doray B, Jennings BC, Lee WS, Liu L, Kornfeld S, Li H
J Biol Chem (2024) 300 pp. 107706-107706 [ Pubmed: 39178950 DOI: doi:10.1016/j.jbc.2024.107706 ]
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glcnac-1-phosphotransferase (268 kDa, Complex from Homo sapiens)
- Uridine-diphosphate-n-acetylglucosamine (607 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (134 kDa, Protein from Homo sapiens)
Cholinephosphotransferase in complex with diacylglycerol
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ul9
Q-score: 0.503
Roberts JR, Horibata Y, Kwarcinski FE, Lam V, Raczkowski AM, Hubbard A, White B, Sugimoto H, Tall GG, Ohi MD, Maeda S
Nat Commun (2025) 16 pp. 111-111 [ Pubmed: 39747155 DOI: doi:10.1038/s41467-024-55673-1 ]
- Water (18 Da, Ligand)
- Cholinephosphotransferase 1 (44 kDa, Protein from Saccharomyces cerevisiae)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Saccharomyces cerevisiae cdp-choline phosphotransferase in complex with diacyl-glycerol (Complex from Saccharomyces cerevisiae)
- Nanobody24 (Complex from Lama glama)
- Magnesium ion (24 Da, Ligand)
- Diacyl glycerol (625 Da, Ligand)
- Ycpt1 (Complex from Saccharomyces cerevisiae)
Structure of Xenopus cholinephosphotransferase1 in complex with CDP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ero
Q-score: 0.49
Nat Commun (2023) 14 pp. 2753-2753 [ DOI: doi:10.1038/s41467-023-38003-9 Pubmed: 37179328 ]
- Homodimer of choline phosphotransferase 1 (Complex from Xenopus laevis)
- Cytidine-5'-diphosphate (403 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholinephosphotransferase 1 (44 kDa, Protein from Xenopus laevis)
Structure of Xenopus cholinephosphotransferase1 in complex with CDP-choline
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8erp
Q-score: 0.466
Nat Commun (2023) 14 pp. 2753-2753 [ DOI: doi:10.1038/s41467-023-38003-9 Pubmed: 37179328 ]
- Homodimer of choline phosphotransferase 1 (Complex from Xenopus laevis)
- [2-cytidylate-o'-phosphonyloxyl]-ethyl-trimethyl-ammonium (488 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cholinephosphotransferase 1 (44 kDa, Protein from Xenopus laevis)
Cryo-EM map of human GlcNAc-1-phosphotransferase A2B2 subcomplex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7s05
Q-score: 0.503
Li H, Lee WS, Feng X, Bai L, Jennings BC, Liu L, Doray B, Canfield WM, Kornfeld S, Li H
Nat Struct Mol Biol (2022) 29 pp. 348-356 [ Pubmed: 35332324 DOI: doi:10.1038/s41594-022-00748-0 ]
- N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (134 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glcnac-1-phosphotransferase (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)