Plasmodium falciparum 20S proteasome bound to an inhibitor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA
Cell Chem Biol (2024) 31 pp. 1503- [ DOI: doi:10.1016/j.chembiol.2024.07.001 Pubmed: 39084225 ]
- Proteasome endopeptidase complex (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (33 kDa, Protein from Plasmodium falciparum 3D7)
- (3s)-1-[(2-fluoroethoxy)acetyl]-n-{[(4p)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide (420 Da, Ligand)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type (23 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (26 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type-6, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome bound with an inhibitor (750 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type-3, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (30 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum NF54)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum NF54)
- Plasmodium falciparum 20s proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (23 kDa, Protein from Plasmodium falciparum NF54)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Water (18 Da, Ligand)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-7 (30 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-5 (23 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-4 (22 kDa, Protein from Plasmodium falciparum Dd2)
- (2s)-n-[(e,2s)-1-(1h-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2s)-3-(1h-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (690 Da, Ligand)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-3 (24 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-6 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-2 (25 kDa, Protein from Plasmodium falciparum Dd2)
- The plasmodium falciparum 20s proteasome beta-6 a117d mutant complexed with inhibitor wlw-vs (700 kDa, Complex from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Plasmodium falciparum Dd2)
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with bortezomib (700 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
Structure of Plasmodium falciparum 20S proteasome with bound ML052.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7lxu
Q-score: 0.524
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-l-prolinamide (352 Da, Ligand)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome complexed with ml052 (700 kDa, Complex from Plasmodium falciparum)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6muv
Q-score: 0.397
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mux
Q-score: 0.439
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
Structure and function based design of Plasmodium-selective proteasome inhibitors
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5fmg
Q-score: 0.47
Li H, O' Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PCA, Bogyo M
Nature (2016) 530 pp. 233-236 [ DOI: doi:10.1038/nature16936 Pubmed: 26863983 ]