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sample_name:"Plasmodium falciparum 20S proteasome"
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Plasmodium falciparum 20S proteasome bound to an inhibitor

Release date: July 31, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576

Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA

Cell Chem Biol (2024) 31 pp. 1503- [ DOI: doi:10.1016/j.chembiol.2024.07.001 Pubmed: 39084225 ]

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Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

Release date: Dec. 20, 2023
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715

Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G

Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]

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Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs

Release date: Dec. 20, 2023
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645

Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G

Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]

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Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.

Release date: Sept. 22, 2021
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498

Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L

PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]

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Structure of Plasmodium falciparum 20S proteasome with bound ML052.

Release date: Sept. 22, 2021
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7lxu
Q-score: 0.524

Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L

PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]

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The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators.

Release date: Aug. 7, 2019
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6muv
Q-score: 0.397

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L

Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]

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The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator.

Release date: Aug. 7, 2019
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mux
Q-score: 0.439

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L

Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]

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