Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (23 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (30 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum NF54)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Water (18 Da, Ligand)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ DOI: doi:10.1038/s41467-023-44077-2 Pubmed: 38097652 ]
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-2 (25 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-5 (23 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-3 (24 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-4 (22 kDa, Protein from Plasmodium falciparum Dd2)
- The plasmodium falciparum 20s proteasome beta-6 a117d mutant complexed with inhibitor wlw-vs (700 kDa, Complex from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-6 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum Dd2)
- (2s)-n-[(e,2s)-1-(1h-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2s)-3-(1h-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (690 Da, Ligand)
- Water (18 Da, Ligand)
- Proteasome subunit beta-7 (30 kDa, Protein from Plasmodium falciparum Dd2)