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was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

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perform basic research in molecular biology

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More about EMBL

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represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

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Structural biology

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Structural biology

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EMBL-EBI: European Bioinformatics Institute

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Epigenetics and neurobiology

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sample_name:"Plasmodium falciparum 20S proteasome" AND xref_links:"pdbekb" AND author_name:"Da"

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EMD-43746

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Plasmodium falciparum 20S proteasome bound to an inhibitor

Release date: July 31, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576

Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA

Cell Chem Biol (2024) 31 pp. 1503- [ Pubmed: 39084225 DOI: doi:10.1016/j.chembiol.2024.07.001 ]

Sample:

Proteasome endopeptidase complex (26 kDa, Protein from Plasmodium falciparum 3D7)
Plasmodium falciparum 20s proteasome bound with an inhibitor (750 kDa, Complex from Plasmodium falciparum 3D7)
Proteasome endopeptidase complex (28 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta type (23 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta (33 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum 3D7)
(3s)-1-[(2-fluoroethoxy)acetyl]-n-{[(4p)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide (420 Da, Ligand)
Proteasome subunit alpha type-3, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta type-6, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum 3D7)
Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum 3D7)

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EMD-23574

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Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.

Release date: Sept. 22, 2021
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498

Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L

PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]

Sample:

20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum)
20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
Plasmodium falciparum 20s proteasome complexed with bortezomib (700 kDa, Complex from Plasmodium falciparum 3D7)
20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))

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EMD-23575

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Structure of Plasmodium falciparum 20S proteasome with bound ML052.

Release date: Sept. 22, 2021
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7lxu
Q-score: 0.524

Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L

PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]

Sample:

20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
Plasmodium falciparum 20s proteasome complexed with ml052 (700 kDa, Complex from Plasmodium falciparum)
20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
N-[(1r)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-l-prolinamide (352 Da, Ligand)
20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))

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