Cryo-EM structure of GPIb-IX Complex
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8wfs
Q-score: 0.418
To Be Published
- Platelet glycoprotein ib alpha chain (15 kDa, Protein from Homo sapiens)
- Gpib-ix complex (Complex from Homo sapiens)
- Platelet glycoprotein ib beta chain (20 kDa, Protein from Homo sapiens)
- Platelet glycoprotein ix (20 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xyd
Q-score: 0.366
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y
Cell Rep (2024) 43 pp. 114422-114422 [ DOI: doi:10.1016/j.celrep.2024.114422 Pubmed: 38943642 ]
- Ptafr-paf g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Platelet-activating factor receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (2r)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8pqw
Q-score: 0.342
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Cytoplasmic dynein-1 bound to dynactin p150 and lis1 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-1 motor domain bound to LIS1
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8pqy
Q-score: 0.387
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Magnesium ion (24 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein-1 bound to lis1 (Complex from Homo sapiens)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 8pqz
Q-score: 0.284
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- Magnesium ion (24 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cytoplasmic dynein-a1/a2 motor domains bound to lis1 (Complex from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
Composite structure of Dynein-Dynactin-JIP3-LIS1
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 8ptk
Q-score: 0.202
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ Pubmed: 38547289 DOI: doi:10.1126/science.adk8544 ]
- C-jun-amino-terminal kinase-interacting protein 3 (65 kDa, Protein from Homo sapiens)
- Dynactin subunits (Complex from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Arp11 (46 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- F-actin-capping protein subunit beta (30 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Dynactin subunit 4 (52 kDa, Protein from Sus scrofa)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Dynactin subunit 3 (21 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Dynein and jip3 (Complex from Homo sapiens)
- Composite structure of dynein-dynactin-jip3-lis1 (Complex)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (44 kDa, Protein from Sus scrofa)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8fdt
Q-score: 0.426
Ton WD, Wang Y, Chai P, Beauchamp-Perez C, Flint NT, Lammers LG, Xiong H, Zhang K, Markus SM
Nat Struct Mol Biol (2023) 30 pp. 1365-1379 [ DOI: doi:10.1038/s41594-023-01010-x Pubmed: 37322240 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Platelet-activating factor acetylhydrolase ib subunit beta (66 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 heavy chain 1,serine--trna ligase (357 kDa, Protein from Homo sapiens)
- Engineered human dynein motor domain in microtubule-unbound state with lis1 complex in the buffer containing atp-vi (490 kDa, Complex from Homo sapiens)
- Vanadate ion (114 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8fdu
Q-score: 0.431
Ton WD, Wang Y, Chai P, Beauchamp-Perez C, Flint NT, Lammers LG, Xiong H, Zhang K, Markus SM
Nat Struct Mol Biol (2023) 30 pp. 1365-1379 [ DOI: doi:10.1038/s41594-023-01010-x Pubmed: 37322240 ]
- Engineered human dynein motor domain in microtubule-unbound state with lis1 complex in the buffer containing atp-vi (490 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1,serine--trna ligase (357 kDa, Protein from Homo sapiens)
- Platelet-activating factor acetylhydrolase ib subunit beta,platelet-activating factor acetylhydrolase ib subunit beta,human lis1 protein with a snap tag (66 kDa, Protein from Homo sapiens)
Tomogram of platelet filopodia in presence of SARS-CoV-2 spike protein
Kuhn CC, Basnet N, Bodakuntla S, Alvarez-Brecht P, Nichols S, Martinez-Sanchez A, Agostini L, Soh YM, Takagi J, Biertumpfel C, Mizuno N
Nat Commun (2023) 14 pp. 620-620 [ Pubmed: 36739444 DOI: doi:10.1038/s41467-023-36279-5 ]
Tomogram of platelet protrusion with microtubule in presence of SARS-CoV-2 spike protein
Kuhn CC, Basnet N, Bodakuntla S, Alvarez-Brecht P, Nichols S, Martinez-Sanchez A, Agostini L, Soh YM, Takagi J, Biertumpfel C, Mizuno N
Nat Commun (2023) 14 pp. 620-620 [ Pubmed: 36739444 DOI: doi:10.1038/s41467-023-36279-5 ]