Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Pleiotropic regulator 1" AND resolution:[4 TO 5} AND author_name:"Will"

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EMD-11693

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Human pre-Bact-2 spliceosome core structure

Release date: Dec. 9, 2020
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7aav
Q-score: 0.393

Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R

Science (2020) 370 [ DOI: doi:10.1126/science.abc3753 Pubmed: 33243851 ]

Sample:

Ubiquitin-like protein 5 (8 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Zinc finger matrin-type protein 2 (23 kDa, Protein from Human)
D-chiro inositol hexakisphosphate (660 Da, Ligand)
U6 snrna (34 kDa, RNA from Human)
Pre-bact-2 spliceosomal core structure (Complex from Homo sapiens)
U2 snrna (60 kDa, RNA from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Pre-mrna-splicing factor 38a (37 kDa, Protein from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
Minx m3 pre-mrna (Complex from synthetic construct)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
Pre-bact-2 spliceosomal core structure (Complex)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
Microfibrillar-associated protein 1 (52 kDa, Protein from Human)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 snrna (36 kDa, RNA from Human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Minx m3 pre-mrna (73 kDa, RNA from synthetic construct)

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