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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

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offer vital services to scientists in the member states

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scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Pre-mRNA-splicing factor ISY1" AND xref_links:"drugbank" AND author_name:"Agafonov"

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EMD-16452

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Human spliceosomal PM5 C* complex

Release date: July 12, 2023
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8c6j
Q-score: 0.353

Dybkov O, Preussner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Luehrmann R

Sci Adv (2023) 9 pp. eadf1785- [ Pubmed: 36867703 DOI: doi:10.1126/sciadv.adf1785 ]

Sample:

U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from Homo sapiens)
Human spliceosomal c* complex assembled on pm5 pre-mrna (Complex from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Prkr-interacting protein 1 (21 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
Nitric oxide synthase-interacting protein (33 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor cwc22 homolog (57 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Pm5 intron (74 kDa, RNA from Homo sapiens)
Potassium ion (39 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Protein fam50a (40 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 3 (18 kDa, Protein from Homo sapiens)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
Splicing factor cactin (88 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
U5 snrna (36 kDa, RNA from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
Sting er exit protein (25 kDa, Protein from Homo sapiens)
Probable atp-dependent rna helicase ddx41 (69 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
Crooked neck-like protein 1 (83 kDa, Protein from Homo sapiens)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
Rna-binding protein 8a (19 kDa, Protein from Homo sapiens)
Protein fam32a (13 kDa, Protein from Homo sapiens)
Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Splicing regulator sde2 (49 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Protein mago nashi homolog (17 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from Homo sapiens)
Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
Pm5 5' exon (78 kDa, RNA from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from Homo sapiens)
Splicing factor ess-2 homolog (52 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
Splicing factor c9orf78 (33 kDa, Protein from Homo sapiens)
Nf-kappa-b-activating protein (47 kDa, Protein from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)

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EMD-11569

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Human C Complex Spliceosome - High-resolution CORE

Release date: Oct. 14, 2020
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6zym
Q-score: 0.498

Bertram K, El Ayoubi L, Dybkov O, Agafonov DE, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Luhrmann R

Mol Cell (2020) 80 pp. 127-139.e6 [ DOI: doi:10.1016/j.molcel.2020.09.012 Pubmed: 33007253 ]

Sample:

Corepressor interacting with rbpj 1 (52 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Human)
Human c complex spliceosome - high resolution core (Complex from Homo sapiens)
U2 snrna (60 kDa, RNA from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Wd repeat-containing protein 70 (73 kDa, Protein from Human)
Pre-mrna-splicing factor atp-dependent rna helicase prp16 (140 kDa, Protein from Human)
Pre-mrna-splicing factor cwc25 homolog (49 kDa, Protein from Human)
Splicing factor yju2 (21 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (107 kDa, Protein from Human)
U6 snrna (25 kDa, RNA from Human)
Pre-mrna-processing-splicing factor 8 (207 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Zinc ion (65 Da, Ligand)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 snrna (36 kDa, RNA from Human)
Pre-mrna-splicing factor rbm22 (25 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
Protein frg1 (29 kDa, Protein from Human)
Pre-mrna (103 kDa, RNA from Human)

[Show more]

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EMDB [2]

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