Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8olu
Q-score: 0.649
Thomas MG, McGonagle K, Rowland P, Robinson DA, Dodd PG, Camino-Diaz I, Campbell L, Cantizani J, Castaneda P, Conn D, Craggs PD, Edwards D, Ferguson L, Fosberry A, Frame L, Goswami P, Hu X, Korczynska J, MacLean L, Martin J, Mutter N, Osuna-Cabello M, Paterson C, Pena I, Pinto EG, Pont C, Riley J, Shishikura Y, Simeons FRC, Stojanovski L, Thomas J, Wrobel K, Young RJ, Zmuda F, Zuccotto F, Read KD, Gilbert IH, Marco M, Miles TJ, Manzano P, De Rycker M
J Med Chem (2023) 66 pp. 10413-10431 [ DOI: doi:10.1021/acs.jmedchem.3c00582 Pubmed: 37506194 ]
- Proteasome subunit beta (30 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- ~{n}-[3-(cyclopropylcarbamoyl)phenyl]-6-oxidanylidene-1-(phenylmethyl)pyridazine-3-carboxamide (388 Da, Ligand)
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (27 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Leishmania tarentolae proteasome 20s subunit in complex with 1-benzyl-n-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide (Complex from Leishmania tarentolae)
- Proteasome subunit beta (33 kDa, Protein from Leishmania tarentolae)
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zyj
Q-score: 0.565
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
J Med Chem (2022) 65 pp. 11776-11787 [ Pubmed: 35993839 DOI: doi:10.1021/acs.jmedchem.2c00791 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- ~{n}-cyclopentyl-6-methyl-4-phenylazanyl-quinoline-2-carboxamide (345 Da, Ligand)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
- Proteasome (840 kDa, Complex from Leishmania tarentolae)