Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Proteasome alpha 1 subunit, putative" AND author_name:"Paterson"

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EMD-16963

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Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide

Release date: Aug. 9, 2023
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8olu
Q-score: 0.649

Thomas MG, McGonagle K, Rowland P, Robinson DA, Dodd PG, Camino-Diaz I, Campbell L, Cantizani J, Castaneda P, Conn D, Craggs PD, Edwards D, Ferguson L, Fosberry A, Frame L, Goswami P, Hu X, Korczynska J, MacLean L, Martin J, Mutter N, Osuna-Cabello M, Paterson C, Pena I, Pinto EG, Pont C, Riley J, Shishikura Y, Simeons FRC, Stojanovski L, Thomas J, Wrobel K, Young RJ, Zmuda F, Zuccotto F, Read KD, Gilbert IH, Marco M, Miles TJ, Manzano P, De Rycker M

J Med Chem (2023) 66 pp. 10413-10431 [ DOI: doi:10.1021/acs.jmedchem.3c00582 Pubmed: 37506194 ]

Sample:

Proteasome subunit beta (30 kDa, Protein from Leishmania tarentolae)
Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
~{n}-[3-(cyclopropylcarbamoyl)phenyl]-6-oxidanylidene-1-(phenylmethyl)pyridazine-3-carboxamide (388 Da, Ligand)
Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
Proteasome subunit beta (27 kDa, Protein from Leishmania tarentolae)
Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
Leishmania tarentolae proteasome 20s subunit in complex with 1-benzyl-n-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide (Complex from Leishmania tarentolae)
Proteasome subunit beta (33 kDa, Protein from Leishmania tarentolae)

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