canine immunoproteasome 20S subunit in complex with compound 2
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8ysx
Q-score: 0.541
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Proteasome subunit beta type-8 (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- [(~{r})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid (334 Da, Ligand)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (24 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (23 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (28 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (21 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (25 kDa, Protein from Canis lupus familiaris)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- 20s immunoproteasome (Complex from Canis lupus familiaris)
canine immunoproteasome 20S subunit in complex with compound 1
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8yvg
Q-score: 0.707
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Proteasome subunit beta type-8 (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- [(1r)-1-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]-3-methyl-butyl]boronic acid (308 Da, Ligand)
- Proteasome subunit beta (21 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (28 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (23 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (25 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- 20s immunoproteasome (Complex from Canis lupus familiaris)
Saratov GA, Baymukhametov TN, Konevega AL, Kudriaeva AA, Belogurov AA
Russ J Bioorganic Chem (2024) 50 pp. 753-765 [ DOI: doi:10.1134/S106816202403035X ]
- Proteasome subunit alpha type-7 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 6a (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (Protein from Homo sapiens)
- Proteasomal ubiquitin receptor adrm1 (Protein from Homo sapiens)
- Proteasome subunit beta type-3 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 9 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 10b (Protein from Homo sapiens)
- Proteasome subunit beta type-1 (Protein from Homo sapiens)
- Proteasome subunit beta type-10 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (his)x6 tev protease site (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 4 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (Protein from Homo sapiens)
- Human 26s immunoproteasome (2 MDa, Complex from Homo sapiens)
- Proteasome subunit beta type-4 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 2 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 8 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (Protein from Homo sapiens)
- Proteasome subunit beta type-2 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (Protein from Homo sapiens)
- Proteasome subunit beta type-9 (Protein from Homo sapiens)
- Proteasome subunit beta type-8 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 6b (Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (Protein from Homo sapiens)
- 26s proteasome regulatory subunit 7 (Protein from Homo sapiens)
PA28alpha-beta in complex with immunoproteasome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7dr6
Q-score: 0.24
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- 20s proteasome purified from bovine spleen in complex of human pa28 (Complex from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dr7
Q-score: 0.448
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- 20s immunoproteasome purified from bovine spleen (Complex from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7drw
Q-score: 0.179
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- 20s immunoproteasome purified from bovine spleen (Complex from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6avo
Q-score: 0.431
Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G
Nat Commun (2017) 8 pp. 1692-1692 [ Pubmed: 29167449 DOI: doi:10.1038/s41467-017-01760-5 ]
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes (Complex from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-10 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-n~4~-tert-butyl-n~2~-(3-phenylpropanoyl)-l-aspartamide (542 Da, Ligand)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-8 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-9 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)