LPA-bound LPAR6 in complex with miniGq
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 9itb
Q-score: 0.576
Duan Y, Xu Z, Hao B, Zhang A, Guo C, He Y
PNAS (2025) 122 pp. e2415426122-e2415426122 [ Pubmed: 39847322 DOI: doi:10.1073/pnas.2415426122 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Lysophosphatidic acid receptor 6 (33 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Engineered minigaq (41 kDa, Protein from Homo sapiens)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl (9e)-octadec-9-enoate (436 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
LPA-bound LPAR6 in complex with miniG13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 9ite
Q-score: 0.558
Duan Y, Xu Z, Hao B, Zhang A, Guo C, He Y
PNAS (2025) 122 pp. e2415426122-e2415426122 [ Pubmed: 39847322 DOI: doi:10.1073/pnas.2415426122 ]
- Lysophosphatidic acid receptor 6 (34 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Engineered miniga13 (26 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl (9e)-octadec-9-enoate (436 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
LPI-bound GPR55 in complex with G13
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8zx4
Q-score: 0.531
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- [(2~{r})-2-oxidanyl-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{r})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (572 Da, Ligand)
- G-protein coupled receptor 55 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
AM251-bound GPR55 in complex with G13
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8zx5
Q-score: 0.426
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{n}-piperidin-1-yl-pyrazole-3-carboxamide (555 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 55 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
LPS-bound P2Y10 in complex with G13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kgg
Q-score: 0.518
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y
Cell Chem Biol (2024) 31 pp. 1899-1908.e5 [ Pubmed: 39265572 DOI: doi:10.1016/j.chembiol.2024.08.005 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Putative p2y purinoceptor 10 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Histamine-bound H4R/Gi complex
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jxt
Q-score: 0.472
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ Pubmed: 38509098 DOI: doi:10.1038/s41467-024-46840-5 ]
- Phosphate ion (94 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
Clozapine-bound H4R/Gi complex
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8jxv
Q-score: 0.447
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ Pubmed: 38509098 DOI: doi:10.1038/s41467-024-46840-5 ]
- Clozapine (326 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jxw
Q-score: 0.513
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ Pubmed: 38509098 DOI: doi:10.1038/s41467-024-46840-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 2-chloranyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine (327 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
Clobenpropit-bound H4R/Gi complex
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8jxx
Q-score: 0.515
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ Pubmed: 38509098 DOI: doi:10.1038/s41467-024-46840-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 3-(1~{h}-imidazol-4-yl)propyl ~{n}'-[(4-chlorophenyl)methyl]carbamimidothioate (308 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8ww2
Q-score: 0.577
Xiong Y, Xu Z, Li X, Wang Y, Zhao J, Wang N, Duan Y, Xia R, Han Z, Qian Y, Liang J, Zhang A, Guo C, Inoue A, Xia Y, Chen Z, He Y
Cell Res (2024) 34 pp. 232-244 [ DOI: doi:10.1038/s41422-024-00932-5 Pubmed: 38287117 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Palmitic acid (256 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- G-protein coupled receptor 3 (35 kDa, Protein from Homo sapiens)