Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Prostaglandin d2 (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of L797591-SSTR1 G protein complex
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xio
Q-score: 0.469
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- L797591-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha-i (41 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(4~{s})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide (607 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of Pasireotide-SSTR1 G protein complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xip
Q-score: 0.384
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- 004-dtr-lys-ty5-phe-a1d5e (1 kDa, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Pasireotide-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
Structure of L796778-SSTR3 G protein complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8xiq
Q-score: 0.462
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Structure of l796778-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Nit-fc0-nle-a1d5b (584 Da, Protein from synthetic construct)
- Somatostatin receptor type 3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of pasireotide-SSTR3 G protein complex
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8xir
Q-score: 0.501
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Pasireotide-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 3 (45 kDa, Protein from Homo sapiens)
- Pasireotide (1 kDa, Protein from synthetic construct)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Palmitic acid (256 Da, Ligand)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hk3
Q-score: 0.438
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- C3ar-gi-apo protein complex (160 kDa, Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hk5
Q-score: 0.456
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Complement c5 (8 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- C5ar1-gi-c5a protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (7 kDa, Protein from Bos taurus)
- C5a anaphylatoxin chemotactic receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Serotonin 1D (5-HT1D) receptor-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7e32
Q-score: 0.495
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE
Nature (2021) 592 pp. 469-473 [ Pubmed: 33762731 DOI: doi:10.1038/s41586-021-03376-8 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1d (57 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Serotonin 1d (5-ht1d) receptor-gi protein complex (Complex)
- Scfv16 (Complex from Mus musculus)
- Receptor-gi protein (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Apo serotonin 1A (5-HT1A) receptor-Gi protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7e2x
Q-score: 0.424
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE
Nature (2021) 592 pp. 469-473 [ Pubmed: 33762731 DOI: doi:10.1038/s41586-021-03376-8 ]
- Palmitic acid (256 Da, Ligand)
- Apo serotonin 1a (5-ht1a) receptor-gi protein complex (Complex from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)