Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- G-protein complex (93 kDa, Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 (consensus map)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Gpr119-gs-nb35 complex (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- G-protein complex (Complex from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- G-protein complex (Complex from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Guanine nucleotide-bindign protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Gs-nb35 complex (110 kDa, Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- G-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8fy8
Q-score: 0.519
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- 2-(5-methoxy-1h-indol-3-yl)-n,n-dimethylethan-1-amine (218 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8fye
Q-score: 0.53
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1h-indole (262 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8fyl
Q-score: 0.525
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8fyt
Q-score: 0.544
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8fyx
Q-score: 0.545
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Buspirone (385 Da, Ligand)
Cryo-EM map of the entire FtsH-HflKC AAA protease
Qiao Z, Yokoyama T, Yan XF, Beh IT, Shi J, Basak S, Akiyama Y, Gao YG
Cell Rep (2022) 39 pp. 110890-110890 [ Pubmed: 35649372 DOI: doi:10.1016/j.celrep.2022.110890 ]