Human RNA Polymerase III Class III Open Pre-initiation Complex 1 (OC1)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 9fso
Q-score: 0.342
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Muller CW, Ramsay EP, Vannini A
Nat Commun (2025) 16 pp. 141-141 [ Pubmed: 39747245 DOI: doi:10.1038/s41467-024-55553-8 ]
- U6_2_template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Tfiiib (Complex from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (55 kDa, Protein from Homo sapiens)
- Isoform 2 of dna-directed rna polymerase iii subunit rpc5 (74 kDa, Protein from Homo sapiens)
- U6_2_non template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (165 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein (22 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Rna polymerase iii class iii open pre-initiation complex 1 (Complex)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
- Human rna polymerase iii (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo)
RNA Polymerase III Class III Open Pre-initation Complex 2 (OC2)
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 9fsp
Q-score: 0.301
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Muller CW, Ramsay EP, Vannini A
Nat Commun (2025) 16 pp. 141-141 [ Pubmed: 39747245 DOI: doi:10.1038/s41467-024-55553-8 ]
- U6_2_template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Tfiiib (Complex from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (55 kDa, Protein from Homo sapiens)
- U6_2_non template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Rna polymerase iii class iii open pre-initation complex 2 (Complex)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (165 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein (22 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
- Human rna polymerase iii (Complex from Homo sapiens)
RNA Polymerase III Class III Melting Pre-Initiation Complex (MC)
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 9fsq
Q-score: 0.294
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Muller CW, Ramsay EP, Vannini A
Nat Commun (2025) 16 pp. 141-141 [ Pubmed: 39747245 DOI: doi:10.1038/s41467-024-55553-8 ]
- U6_2_template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Tfiiib (Complex from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (55 kDa, Protein from Homo sapiens)
- U6_2_non template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Rna polymerase iii class iii melting pre-initiation complex (Complex)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (165 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein (22 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
- Human rna polymerase iii (Complex from Homo sapiens)
RNA Polymerase III Class III Open Mini Pre-initiation Complex 1 (OC1-mini)
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 9fsr
Q-score: 0.33
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Muller CW, Ramsay EP, Vannini A
Nat Commun (2025) 16 pp. 141-141 [ Pubmed: 39747245 DOI: doi:10.1038/s41467-024-55553-8 ]
- U6_2_template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Rna polymerase iii class iii open mini pre-initiation complex 1 (Complex)
- Tfiiib (Complex from Homo sapiens)
- Rna polymerase iii (Complex from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (55 kDa, Protein from Homo sapiens)
- U6_2_non template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (165 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein (22 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
RNA Polymerase III Class III Open Mini Pre-Initiation complex 2 (OC2-mini)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 9fss
Q-score: 0.264
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Muller CW, Ramsay EP, Vannini A
Nat Commun (2025) 16 pp. 141-141 [ Pubmed: 39747245 DOI: doi:10.1038/s41467-024-55553-8 ]
- U6_2_template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Tfiiib (Complex from Homo sapiens)
- Rna polymerase iii (Complex from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (55 kDa, Protein from Homo sapiens)
- U6_2_non template (30 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Rna polymerase iii class iii open mini pre-initiation complex 2 (Complex)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (165 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein (22 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
Cryo-EM structure of Dopamine 3 Receptor:Go complex bound to bitopic FOB02-04A - Conformation A
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 9f33
Q-score: 0.528
Arroyo-Urea S, Nazarova AL, Carrion-Antoli A, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, Garcia-Nafria J
Nat Commun (2024) 15 pp. 7759-7759 [ DOI: doi:10.1038/s41467-024-51993-4 Pubmed: 39237617 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Green fluorescent protein,d(3) dopamine receptor (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- N-[2-[(1r,2s)-2-[[(2s,5s)-2-(6-azanylpyridin-3-yl)-5-methyl-morpholin-4-yl]methyl]cyclopropyl]ethyl]-1h-indole-2-carboxamide (433 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- D3r:go protein complex with bitopic fob02-04a-conformation a (190 kDa, Complex from Homo sapiens)
- Antibody scfv16 (28 kDa, Protein from Mus musculus)
Full agonist-bound mu-type opioid receptor-G protein complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8k9k
Q-score: 0.543
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- Full agonist-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
- Guanine nucleotide binding protein, beta polypeptide 1 (38 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from synthetic construct)
Structure of FFAR1-Gq complex bound to DHA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8eit
Q-score: 0.529
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ejc
Q-score: 0.522
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ejk
Q-score: 0.488
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)