Full agonist-bound mu-type opioid receptor-G protein complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8k9k
Q-score: 0.543
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- Scfv16 (27 kDa, Protein from synthetic construct)
- Soluble cytochrome b562,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide binding protein, beta polypeptide 1 (38 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from synthetic construct)
- Full agonist-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
Structure of the full-length IP3R1 channel determined at high Ca2+
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8eaq
Q-score: 0.403
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II
Nat Commun (2022) 13 pp. 6942-6942 [ Pubmed: 36376291 DOI: doi:10.1038/s41467-022-34574-1 ]
- Inositol 1,4,5-trisphosphate receptor type 1 (313 kDa, Protein from Rattus norvegicus)
- Zinc ion (65 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ear
Q-score: 0.35
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II
Nat Commun (2022) 13 pp. 6942-6942 [ Pubmed: 36376291 DOI: doi:10.1038/s41467-022-34574-1 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol 1,4,5-trisphosphate receptor type 1 (313 kDa, Protein from Rattus norvegicus)
- Zinc ion (65 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
Molecular mechanism of the the wake-promoting agent TAK-925
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sr8
Q-score: 0.457
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Human orexin receptor 2 - g protein complex (Complex from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Hypocretin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7ra3
Q-score: 0.436
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ DOI: doi:10.1073/pnas.2116506119 Pubmed: 35333651 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Gastric inhibitory polypeptide gip bound to gip receptor gipr (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Gastric inhibitory polypeptide receptor (52 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide (4 kDa, Protein from Homo sapiens)
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
- Cryo-em of human gastric inhibitory polypeptide receptor gipr bound to gip, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 7rbt
Q-score: 0.479
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ DOI: doi:10.1073/pnas.2116506119 Pubmed: 35333651 ]
- Cryo-em of human gastric inhibitory polypeptide receptor gipr bound to tirzepatide, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
- Tirzepatide (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Tirzepatide bound to gip receptor gipr (Complex from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor (52 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- 2-fluoro-4-[(1r)-6-methoxy-1-methyl-2-{(1s)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol (504 Da, Ligand)
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7rg9
Q-score: 0.476
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ DOI: doi:10.1073/pnas.2116506119 Pubmed: 35333651 ]
- Glucagon-like peptide 1 receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em of apo form human glucagon-like peptide 1 receptor glp-1r, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor in apo form (Complex from Homo sapiens)
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7rgp
Q-score: 0.484
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ DOI: doi:10.1073/pnas.2116506119 Pubmed: 35333651 ]
- Glucagon-like peptide 1 receptor (51 kDa, Protein from Homo sapiens)
- Tirzepatide (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Cryo-em of human glucagon-like peptide 1 receptor glp-1r bound to tirzepatide, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor bound to tirzepatide (Complex from Homo sapiens)
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
34-fold symmetry Salmonella S ring formed by full-length FliF
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7d84
Q-score: 0.447
Kawamoto A, Miyata T, Makino F, Kinoshita M, Minamino T, Imada K, Kato T, Namba K
Nat Commun (2021) 12 pp. 4223-4223 [ DOI: doi:10.1038/s41467-021-24507-9 Pubmed: 34244518 ]
Pincer of the human TSC protein complex
Ramlaul K, Fu W, Li H, de Martin Garrido N, He L, Trivedi M, Cui W, Aylett CHS, Wu G
J Mol Biol (2020) 433 pp. 166743-166743 [ Pubmed: 33307091 DOI: doi:10.1016/j.jmb.2020.166743 ]
- Pincer of the human tsc protein complex (700 MDa, Complex from Homo sapiens)
- Tuberin (Protein from Homo sapiens)
- Hamartin (Protein from Homo sapiens)
- Tbc1d7 (Protein from Homo sapiens)