Structure of the full-length IP3R1 channel determined at high Ca2+
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8eaq
Q-score: 0.403
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II
Nat Commun (2022) 13 pp. 6942-6942 [ Pubmed: 36376291 DOI: doi:10.1038/s41467-022-34574-1 ]
- Inositol 1,4,5-trisphosphate receptor type 1 (313 kDa, Protein from Rattus norvegicus)
- Zinc ion (65 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ear
Q-score: 0.35
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II
Nat Commun (2022) 13 pp. 6942-6942 [ Pubmed: 36376291 DOI: doi:10.1038/s41467-022-34574-1 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol 1,4,5-trisphosphate receptor type 1 (313 kDa, Protein from Rattus norvegicus)
- Zinc ion (65 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7lhe
Q-score: 0.346
Baker MR, Fan G, Seryshev AB, Agosto MA, Baker ML, Serysheva II
Commun Biol (2021) 4 pp. 625- [ DOI: doi:10.1038/s42003-021-02156-4 ]
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Inositol 1,4,5-trisphosphate receptor type 1 (311 kDa, Protein from Rattus norvegicus)
- Zinc ion (65 Da, Ligand)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)
Structure of full-length IP3R1 channel solubilized in LNMG lipid in the apo-state
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7lhf
Q-score: 0.376
Baker MR, Fan G, Seryshev AB, Agosto MA, Baker ML, Serysheva II
Commun Biol (2021) 4 pp. 625- [ DOI: doi:10.1038/s42003-021-02156-4 ]
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Inositol 1,4,5-trisphosphate receptor type 1 (312 kDa, Protein from Rattus norvegicus)
- Type 1 inositol 1,4,5-trisphosphate receptor tetrameric protein complex (1 MDa, Complex from Rattus norvegicus)