Cryo-EM structure of a class A GPCR-G protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7v69
Q-score: 0.324
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T
Nat Commun (2022) 13 pp. 2855-2855 [ DOI: doi:10.1038/s41467-022-30595-y Pubmed: 35606397 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- M4r-iperoxo and gi protein complex (Complex from Homo sapiens)
- M4r-iperoxo (Complex)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- Gi protein (Complex from Homo sapiens)
Cryo-EM structure of a class A GPCR with G protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kpf
Q-score: 0.556
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ
Cell (2020) 180 pp. 655- [ DOI: doi:10.1016/j.cell.2020.01.008 Pubmed: 32004463 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 2 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpcr-g protein complex (130 MDa, Complex from Homo sapiens)
- 7-[(6ar,9r,10ar)-1-hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6h-benzo[c]chromen-3-yl]- 7-methyloctanenitrile (399 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of CB1-G protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6kpg
Q-score: 0.501
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ
Cell (2020) 180 pp. 655- [ DOI: doi:10.1016/j.cell.2020.01.008 Pubmed: 32004463 ]
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cb1-g protein complex (140 MDa, Complex from Homo sapiens)
- (6~{a}~{r},9~{r},10~{a}~{r})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol (445 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)