Structure of the human BOS:human EMC complex in GDN
Resolution: 6.6 Å
EM Method: Single-particle
Fitted PDBs: 9c7v
Q-score: 0.166
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM
Mol Cell (2024) 84 pp. 3302- [ Pubmed: 39173640 DOI: doi:10.1016/j.molcel.2024.08.005 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Human bos complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Nicalin (63 kDa, Protein from Homo sapiens)
- Transmembrane protein 147 (25 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Bos complex subunit nomo2 (139 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
LPS-bound P2Y10 in complex with G13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kgg
Q-score: 0.518
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y
Cell Chem Biol (2024) 31 pp. 1899-1908.e5 [ Pubmed: 39265572 DOI: doi:10.1016/j.chembiol.2024.08.005 ]
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- Putative p2y purinoceptor 10 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8pjk
Q-score: 0.611
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- St171-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{h}-1,4-benzoxazin-3-one (372 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8pkm
Q-score: 0.468
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone (393 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Befiradol-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Full agonist-bound mu-type opioid receptor-G protein complex
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8k9k
Q-score: 0.543
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- Scfv16 (27 kDa, Protein from synthetic construct)
- Soluble cytochrome b562,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide binding protein, beta polypeptide 1 (38 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from synthetic construct)
- Full agonist-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8k9l
Q-score: 0.505
Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I
Nat Commun (2024) 15 pp. 3544-3544 [ DOI: doi:10.1038/s41467-024-47792-6 Pubmed: 38740791 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Damgo (513 Da, Protein from synthetic construct)
- Soluble cytochrome b562,mu-type opioid receptor,mu-type opioid receptor (51 kDa, Protein from Homo sapiens)
- Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- G protein subunit alpha i3 (40 kDa, Protein from Macaca mulatta)
- (2~{s})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine (448 Da, Ligand)
The structure of PSI-11CAC at the stationary growth phase
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8wmw
Q-score: 0.526
Zhang S, Si L, Su X, Zhao X, An X, Li M
Commun Biol (2024) 7 pp. 560-560 [ DOI: doi:10.1038/s42003-024-06268-5 Pubmed: 38734819 ]
- Cac-a (23 kDa, Protein from Rhodomonas salina)
- Chlorophyll c2 (608 Da, Ligand)
- Psao (15 kDa, Protein from Rhodomonas salina)
- Cac-d (22 kDa, Protein from Rhodomonas salina)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Photosystem i reaction center subunit xii (3 kDa, Protein from Rhodomonas salina)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Cac-b (23 kDa, Protein from Rhodomonas salina)
- (1~{r})-3,5,5-trimethyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e})-3,7,12,16-tetramethyl-18-[(4~{r})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-3,5,7,9,11,13,15-heptaen-1,17-diynyl]cyclohex-3-en-1-ol (564 Da, Ligand)
- 1,3,3-trimethyl-2-[(1e,3e,5e,7e,9e,11e,13e,15e,17e)-3,7,12,16-tetramethyl-18-[(1r)-2,6,6-trimethylcyclohex-2-en-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene (536 Da, Ligand)
- Cac-c (23 kDa, Protein from Rhodomonas salina)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Pigment binding protein complex (Complex from Rhodomonas salina)
- Cac-i (23 kDa, Protein from Rhodomonas salina)
- Photosystem i p700 chlorophyll a apoprotein a2 (82 kDa, Protein from Rhodomonas salina)
- Photosystem i iron-sulfur center (8 kDa, Protein from Rhodomonas salina)
- Photosystem i reaction center subunit ix (4 kDa, Protein from Rhodomonas salina)
- Photosystem i reaction center subunit iv (7 kDa, Protein from Rhodomonas salina)
- Dodecyl-alpha-d-maltoside (510 Da, Ligand)
- Photosystem i reaction center subunit ii (15 kDa, Protein from Rhodomonas salina)
- Cac-e (21 kDa, Protein from Rhodomonas salina)
- (1~{r})-3,5,5-trimethyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-3,5,7,9,11,13,15,17-octaen-1-ynyl]cyclohex-3-en-1-ol (550 Da, Ligand)
- Photosystem i reaction center subunit xi (16 kDa, Protein from Rhodomonas salina)
- Photosystem i reaction center subunit psak (8 kDa, Protein from Rhodomonas salina)
- Cac-f (22 kDa, Protein from Rhodomonas salina)
- Cac-g (26 kDa, Protein from Rhodomonas salina)
- Phylloquinone (450 Da, Ligand)
- Photosystem i reaction center subunit iii (20 kDa, Protein from Rhodomonas salina)
- Photosystem i p700 chlorophyll a apoprotein a1 (83 kDa, Protein from Rhodomonas salina)
- Photosystem i reaction center subunit viii (3 kDa, Protein from Rhodomonas salina)
- Chlorophyll a (893 Da, Ligand)
- Water (18 Da, Ligand)
- Cac-h (23 kDa, Protein from Rhodomonas salina)
- Iron/sulfur cluster (351 Da, Ligand)
- Psar (13 kDa, Protein from Rhodomonas salina)
- Cac-k (25 kDa, Protein from Rhodomonas salina)
cryo-EM structure of human EMC
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8j0n
Q-score: 0.031
Li M, Zhang C, Xu Y, Li S, Huang C, Wu J, Lei M
Aging (Albany NY) (2024) 16 pp. 5501-5525 [ DOI: doi:10.18632/aging.205660 Pubmed: 38517390 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Emc (Complex from Homo sapiens)
- Er membrane protein complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (14 kDa, Protein from Homo sapiens)
cryo-EM structure of human EMC and VDAC
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8j0o
Q-score: 0.017
Li M, Zhang C, Xu Y, Li S, Huang C, Wu J, Lei M
Aging (Albany NY) (2024) 16 pp. 5501-5525 [ DOI: doi:10.18632/aging.205660 Pubmed: 38517390 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Voltage-dependent anion-selective channel protein 1 (30 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Emc_vdac (Complex from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (14 kDa, Protein from Homo sapiens)
Structure of MK6892-GPR109A-G-protein complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8iyh
Q-score: 0.498
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Scfv16 antibody (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Structure of mk6892-gpr109a-g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)