Structure of FFAR1-Gq complex bound to DHA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8eit
Q-score: 0.529
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ejc
Q-score: 0.522
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ejk
Q-score: 0.488
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
Molecular mechanism of the the wake-promoting agent TAK-925
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sr8
Q-score: 0.457
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Human orexin receptor 2 - g protein complex (Complex from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Hypocretin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6vms
Q-score: 0.38
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM
Nature (2020) 584 pp. 125-129 [ DOI: doi:10.1038/s41586-020-2379-5 Pubmed: 32528175 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- D2 dopamine receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Rattus norvegicus)
- Endolysin,d(2) dopamine receptor,d(2) dopamine receptor (51 kDa, Protein from Homo sapiens)
- Bromoergocryptine (654 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
cryoEM structure of membrane protein complex
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6c14
Q-score: 0.269
Ge J, Elferich J, Goehring A, Zhao J, Schuck P, Gouaux E
eLife (2018) 7 [ Pubmed: 30070639 DOI: doi:10.7554/eLife.38770 ]
- Lhfpl tetraspan subfamily member 5 protein (25 kDa, Protein from Mus musculus)
- Membrane protein complex (Complex from Mus musculus)
- Protocadherin-15 (37 kDa, Protein from Mus musculus)