Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Prostaglandin d2 (352 Da, Ligand)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
Structure of L797591-SSTR1 G protein complex
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xio
Q-score: 0.469
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- G-alpha-i (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- L797591-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(4~{s})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide (607 Da, Ligand)
Structure of Pasireotide-SSTR1 G protein complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xip
Q-score: 0.384
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Pasireotide-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 004-dtr-lys-ty5-phe-a1d5e (1 kDa, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
Structure of L796778-SSTR3 G protein complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8xiq
Q-score: 0.462
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Somatostatin receptor type 3 (40 kDa, Protein from Homo sapiens)
- Structure of l796778-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nit-fc0-nle-a1d5b (584 Da, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
Structure of pasireotide-SSTR3 G protein complex
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8xir
Q-score: 0.501
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Somatostatin receptor type 3 (45 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Pasireotide-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- Pasireotide (1 kDa, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8x8l
Q-score: 0.493
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ Pubmed: 38885377 DOI: doi:10.1073/pnas.2321710121 ]
- Cortistatin (2 kDa, Protein from Homo sapiens)
- Cortistatin 17-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x8n
Q-score: 0.483
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ Pubmed: 38885377 DOI: doi:10.1073/pnas.2321710121 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Octreotide (1 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
PSI-AcpPCI supercomplex from Amphidinium carterae
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jw0
Q-score: 0.51
Li X, Li Z, Wang F, Zhao S, Xu C, Mao Z, Duan J, Feng Y, Yang Y, Shen L, Wang G, Yang Y, Yu LJ, Sang M, Han G, Wang X, Kuang T, Shen JR, Wang W
PNAS (2024) 121 pp. e2315476121-e2315476121 [ Pubmed: 38319970 DOI: doi:10.1073/pnas.2315476121 ]
- Peridinin (630 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-11, acppci-11 (19 kDa, Protein from Amphidinium carterae)
- Beta-carotene (536 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-14, acppci-14 (17 kDa, Protein from Amphidinium carterae)
- Photosystem i psab (67 kDa, Protein from Amphidinium carterae)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- (3s,3'r,5r,6s,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol (582 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-15, acppci-15 (17 kDa, Protein from Amphidinium carterae)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Photosystem i psaj (7 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-5, acppci-5 (20 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-9, acppci-9 (17 kDa, Protein from Amphidinium carterae)
- Photosystem i psaf (20 kDa, Protein from Amphidinium carterae)
- Psi-acppci supercomplex from amphidinium carterae (Complex from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-12, acppci-12 (17 kDa, Protein from Amphidinium carterae)
- Photosystem i psai (14 kDa, Protein from Amphidinium carterae)
- Photosystem i psar (14 kDa, Protein from Amphidinium carterae)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-6, acppci-6 (19 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-10, acppci-10 (19 kDa, Protein from Amphidinium carterae)
- Photosystem i psam (9 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-7, acppci-7 (21 kDa, Protein from Amphidinium carterae)
- Photosystem i psaa (70 kDa, Protein from Amphidinium carterae)
- Photosystem i psad (28 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-8, acppci-8 (23 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-2, acppci-2 (19 kDa, Protein from Amphidinium carterae)
- Photosystem i psae (8 kDa, Protein from Amphidinium carterae)
- Photosystem i psac (9 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-13, acppci-13 (17 kDa, Protein from Amphidinium carterae)
- Phylloquinone (450 Da, Ligand)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- Chlorophyll a (893 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-3, acppci-3 (18 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-4, acppci-4 (18 kDa, Protein from Amphidinium carterae)
- Photosystem i psal (27 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-16, acppci-16 (17 kDa, Protein from Amphidinium carterae)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-1, acppci-1 (15 kDa, Protein from Amphidinium carterae)
- Iron/sulfur cluster (351 Da, Ligand)
- [(1~{s},5~{r})-3,3,5-trimethyl-5-oxidanyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(1~{s},4~{s},6~{r})-2,2,6-trimethyl-4-oxidanyl-7-oxabicyclo[4.1.0]heptan-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenylidene]cyclohexyl] ethanoate (642 Da, Ligand)
- Chlorophyll c1 (610 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-17, acppci-17 (17 kDa, Protein from Amphidinium carterae)
PSI-AcpPCI supercomplex from Symbiodinium
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8jze
Q-score: 0.518
Li X, Li Z, Wang F, Zhao S, Xu C, Mao Z, Duan J, Feng Y, Yang Y, Shen L, Wang G, Yang Y, Yu LJ, Sang M, Han G, Wang X, Kuang T, Shen JR, Wang W
PNAS (2024) 121 pp. e2315476121-e2315476121 [ Pubmed: 38319970 DOI: doi:10.1073/pnas.2315476121 ]
- Peridinin (630 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-8, acppci-8 (24 kDa, Protein from Symbiodinium)
- Photosystem i unk (11 kDa, Protein from Symbiodinium)
- Beta-carotene (536 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-4, acppci-4 (19 kDa, Protein from Symbiodinium)
- (3s,3'r,5r,6s,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol (582 Da, Ligand)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-6, acppci-6 (19 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-12, acppci-12 (17 kDa, Protein from Symbiodinium)
- Photosystem i unk (6 kDa, Protein from Symbiodinium)
- Photosystem i psai (13 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-2, acppci-2 (19 kDa, Protein from Symbiodinium)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-7, acppci-7 (21 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-15, acppci-15 (17 kDa, Protein from Symbiodinium)
- Photosystem i psad (24 kDa, Protein from Symbiodinium)
- Photosystem i psal (27 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-3, acppci-3 (22 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-10, acppci-10 (20 kDa, Protein from Symbiodinium)
- Photosystem i psae (8 kDa, Protein from Symbiodinium)
- Phylloquinone (450 Da, Ligand)
- Photosystem i psaa (75 kDa, Protein from Symbiodinium)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- Psi-acppci supercomplex from symbiodinium (Complex from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-13, acppci-13 (17 kDa, Protein from Symbiodinium)
- Photosystem i psar (15 kDa, Protein from Symbiodinium)
- Chlorophyll a (893 Da, Ligand)
- Photosystem i psaf (20 kDa, Protein from Symbiodinium)
- Photosystem i psaj (11 kDa, Protein from Symbiodinium)
- [(1~{s},5~{r})-3,3,5-trimethyl-5-oxidanyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(1~{s},4~{s},6~{r})-2,2,6-trimethyl-4-oxidanyl-7-oxabicyclo[4.1.0]heptan-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenylidene]cyclohexyl] ethanoate (642 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-11, acppci-11 (21 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-14, acppci-14 (17 kDa, Protein from Symbiodinium)
- Chlorophyll c1 (610 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-9, acppci-9 (17 kDa, Protein from Symbiodinium)
- Photosystem i psab (74 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-5, acppci-5 (20 kDa, Protein from Symbiodinium)
- Photosystem i psac (9 kDa, Protein from Symbiodinium)
- Photosystem i psam (8 kDa, Protein from Symbiodinium)
PSI-AcpPCI supercomplex from Symbiodinium
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8jzf
Q-score: 0.537
Li X, Li Z, Wang F, Zhao S, Xu C, Mao Z, Duan J, Feng Y, Yang Y, Shen L, Wang G, Yang Y, Yu LJ, Sang M, Han G, Wang X, Kuang T, Shen JR, Wang W
PNAS (2024) 121 pp. e2315476121-e2315476121 [ Pubmed: 38319970 DOI: doi:10.1073/pnas.2315476121 ]
- Peridinin (630 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-8, acppci-8 (24 kDa, Protein from Symbiodinium)
- Photosystem i unk (11 kDa, Protein from Symbiodinium)
- Beta-carotene (536 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-4, acppci-4 (19 kDa, Protein from Symbiodinium)
- (3s,3'r,5r,6s,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol (582 Da, Ligand)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-6, acppci-6 (19 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-12, acppci-12 (17 kDa, Protein from Symbiodinium)
- Photosystem i unk (6 kDa, Protein from Symbiodinium)
- Photosystem i psai (13 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-2, acppci-2 (19 kDa, Protein from Symbiodinium)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-7, acppci-7 (21 kDa, Protein from Symbiodinium)
- Photosystem i psad (24 kDa, Protein from Symbiodinium)
- Photosystem i psal (27 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-3, acppci-3 (22 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-10, acppci-10 (20 kDa, Protein from Symbiodinium)
- Photosystem i psae (8 kDa, Protein from Symbiodinium)
- Phylloquinone (450 Da, Ligand)
- Photosystem i psaa (75 kDa, Protein from Symbiodinium)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- Psi-acppci supercomplex from symbiodinium (Complex from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-13, acppci-13 (17 kDa, Protein from Symbiodinium)
- Photosystem i psar (15 kDa, Protein from Symbiodinium)
- Chlorophyll a (893 Da, Ligand)
- Photosystem i psaf (20 kDa, Protein from Symbiodinium)
- Photosystem i psaj (11 kDa, Protein from Symbiodinium)
- [(1~{s},5~{r})-3,3,5-trimethyl-5-oxidanyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(1~{s},4~{s},6~{r})-2,2,6-trimethyl-4-oxidanyl-7-oxabicyclo[4.1.0]heptan-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenylidene]cyclohexyl] ethanoate (642 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-11, acppci-11 (21 kDa, Protein from Symbiodinium)
- Chlorophyll c1 (610 Da, Ligand)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-9, acppci-9 (17 kDa, Protein from Symbiodinium)
- Photosystem i psab (74 kDa, Protein from Symbiodinium)
- Chlorophyll a-chlorophyll c-peridinin-protein-complex i-5, acppci-5 (20 kDa, Protein from Symbiodinium)
- Photosystem i psac (9 kDa, Protein from Symbiodinium)
- Photosystem i psam (8 kDa, Protein from Symbiodinium)