Hsp90 provides platform for CRaf dephosphorylation by PP5
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8gft
Q-score: 0.333
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Homo sapiens)
- Hsp90 co-chaperone cdc37, n-terminally processed (45 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Serine/threonine-protein phosphatase 5 (57 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90:cdc37:craf:pp5 complex (57 kDa, Complex from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (34 kDa, Protein from Homo sapiens)
Hsp90 provides platform for CRaf dephosphorylation by PP5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gae
Q-score: 0.326
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Heat shock protein hsp 90-beta (83 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Serine/threonine-protein phosphatase 5 (57 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Raf proto-oncogene serine/threonine-protein kinase (23 kDa, Protein from Homo sapiens)
- Hsp90 co-chaperone cdc37 (45 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90:cdc37:craf:pp5 complex (57 kDa, Complex from Homo sapiens)
PP5 TPR domain bound to Hsp90:Cdc37:CRaf complex
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5 tpr domain. (57 kDa, Complex from Homo sapiens)
PP5 bound to Hsp90:Cdc37:CRaf complex
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5. (57 kDa, Complex from Homo sapiens)
PP5 bound to Hsp90:Cdc37:CRaf complex (conformation II)
Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Nat Commun (2023) 14 pp. 2197-2197 [ DOI: doi:10.1038/s41467-023-37659-7 Pubmed: 37069154 ]
- Raf proto-oncogene serine/threonine-protein kinase (Protein from Homo sapiens)
- Heat shock protein hsp 90-beta (Protein from Homo sapiens)
- Hsp90 co-chaperone cdc37 (Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 5 (Protein from Homo sapiens)
- Protein phosphatase 5 (h304a) (Complex from Homo sapiens)
- Hsp90:cdc37:craf complex bound to pp5. (57 kDa, Complex from Homo sapiens)