Structure of Mammalian NALCN-FAM155A-UNC79-UNC80 quanternary complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w7g
Q-score: 0.42
Nat Commun (2022) 13 pp. 2639-2639 [ Pubmed: 35550517 DOI: doi:10.1038/s41467-022-30403-7 ]
- Transmembrane protein fam155a (52 kDa, Protein from Mus musculus)
- Sodium leak channel non-selective protein (200 kDa, Protein from Rattus norvegicus)
- Protein unc-79 homolog (297 kDa, Protein from Mus musculus)
- Protein unc-80 homolog (371 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nalcn-fam155a-unc79-unc80 complex (Complex from Mus musculus)
Architecture of the human NALCN channelosome
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7wji
Q-score: 0.139
Zhou L, Liu H, Zhao Q, Wu J, Yan Z
Cell Discov (2022) 8 pp. 33-33 [ DOI: doi:10.1038/s41421-022-00392-4 Pubmed: 35387979 ]
- Nalcn channelosome (900 kDa, Complex from Homo sapiens)
- Sodium leak channel non-selective protein,extended tegument protein pp150 (229 kDa, Protein from Homo sapiens)
- Protein unc-79 homolog (298 kDa, Protein from Homo sapiens)
- Protein unc-80 homolog (363 kDa, Protein from Homo sapiens)
- Transmembrane protein fam155a (51 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sx3
Q-score: 0.47
Kschonsak M, Chua HC, Weidling C, Chakouri N, Noland CL, Schott K, Chang T, Tam C, Patel N, Arthur CP, Leitner A, Ben-Johny M, Ciferri C, Pless SA, Payandeh J
Nature (2022) 603 pp. 180-186 [ DOI: doi:10.1038/s41586-021-04313-5 Pubmed: 34929720 ]
- Sodium leak channel non-selective protein,enhanced green fluorescent protein (234 kDa, Protein from Homo sapiens)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (720 Da, Ligand)
- Transmembrane protein fam155a (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Pentameric complex of the leak channel nalcn with fam155a, calmodulin, unc79 and unc80 (Complex from Homo sapiens)
- (1r)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11e)-octadec-11-enoate (749 Da, Ligand)
- Unc79,protein unc-79 homolog,protein unc-79 homolog (285 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein unc-80 homolog (366 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sx4
Q-score: 0.359
Kschonsak M, Chua HC, Weidling C, Chakouri N, Noland CL, Schott K, Chang T, Tam C, Patel N, Arthur CP, Leitner A, Ben-Johny M, Ciferri C, Pless SA, Payandeh J
Nature (2022) 603 pp. 180-186 [ DOI: doi:10.1038/s41586-021-04313-5 Pubmed: 34929720 ]
- Sodium leak channel non-selective protein,enhanced green fluorescent protein (234 kDa, Protein from Homo sapiens)
- Unc79,protein unc-79 homolog (285 kDa, Protein from Homo sapiens)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (720 Da, Ligand)
- Transmembrane protein fam155a (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Pentameric complex of the leak channel nalcn with fam155a, calmodulin, unc79 and unc80 (Complex from Homo sapiens)
- (1r)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11e)-octadec-11-enoate (749 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein unc-80 homolog (366 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)