Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7try
Q-score: 0.338
Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE
Nat Commun (2022) 13 pp. 6670-6670 [ Pubmed: 36335102 DOI: doi:10.1038/s41467-022-33851-3 ]
- Corticotropin releasing factor receptor 2 (crf2r) bound to urocortin 1 (ucn1) and coupled with g11 proteins (Complex from Homo sapiens)
- G protein gamma subunit (7 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein subunit alpha-11 (41 kDa, Protein from Homo sapiens)
- Corticotropin-releasing factor receptor 2 (63 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Urocortin (4 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ts0
Q-score: 0.494
Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE
Nat Commun (2022) 13 pp. 6670-6670 [ Pubmed: 36335102 DOI: doi:10.1038/s41467-022-33851-3 ]
- Dominant negative go alpha subunit (40 kDa, Protein from Homo sapiens)
- Corticotropin releasing factor receptor 2 (crf2r) bound to urocortin 1 (ucn1) and coupled with g11 proteins (Complex from Homo sapiens)
- Corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,human corticotropin releasing factor receptor 2 (63 kDa, Protein from Homo sapiens)
- G protein gamma subunit (7 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Urocortin (4 kDa, Protein from Homo sapiens)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7fih
Q-score: 0.382
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ Pubmed: 34552239 DOI: doi:10.1038/s41586-021-03924-2 ]
- 5-azanyl-n-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide (514 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex (Complex)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Glycoprotein hormones alpha chain (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Luteinizing hormone (Complex from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Chorionic gonadotropin (Complex from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7fii
Q-score: 0.326
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ Pubmed: 34552239 DOI: doi:10.1038/s41586-021-03924-2 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-gs complex (Complex)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (Complex from Homo sapiens)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Choriogonadotropin subunit beta 3 (Complex from Homo sapiens)
- Gs proteins (Complex from Bos taurus)
Resolution: 6.7 Å
EM Method: Single-particle
Fitted PDBs: 6njl
Q-score: 0.001
Zhao Y, Chen S, Swensen AC, Qian WJ, Gouaux E
Science (2019) 364 pp. 355-362 [ Pubmed: 30975770 DOI: doi:10.1126/science.aaw8250 ]
- Glutamate receptor 1 (101 kDa, Protein from Rattus norvegicus)
- A'/c' auxiliary proteins (13 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
- 15f1 fab heavy chain (27 kDa, Protein from Mus musculus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Native a1a2a1a2 complex bound with mpqx (Complex from Rattus norvegicus)
- 11b8 scfv (27 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 15f1 fab light chain (25 kDa, Protein from Mus musculus)
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6njm
Q-score: -0.005
Zhao Y, Chen S, Swensen AC, Qian WJ, Gouaux E
Science (2019) 364 pp. 355-362 [ Pubmed: 30975770 DOI: doi:10.1126/science.aaw8250 ]
- Atd-lbd layers of native a3a2a3a2 nampar complex (Complex from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 3 (100 kDa, Protein from Rattus norvegicus)
- A'-c' auxiliary proteins (13 kDa, Protein from Rattus norvegicus)
- 15f1 fab heavy chain (27 kDa, Protein from Mus musculus)
- 5b2 fab light chain (18 kDa, Protein from Rattus norvegicus)
- Native a3a2a3a2 complex bound with mpqx (Complex from Rattus norvegicus)
- Lbd-tmd layers of native a3a2a3a2 nampar complex (Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- 5b2 fab heavy chain (21 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 15f1 fab light chain (25 kDa, Protein from Mus musculus)
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6njn
Q-score: 0.012
Zhao Y, Chen S, Swensen AC, Qian WJ, Gouaux E
Science (2019) 364 pp. 355-362 [ Pubmed: 30975770 DOI: doi:10.1126/science.aaw8250 ]
- Glutamate receptor 1 (101 kDa, Protein from Rattus norvegicus)
- Atd-lbd layers of native tri-heteromeric a1a2a3a2 ampar (Complex from Rattus norvegicus)
- Atd layer of native tri-heteromeric a1a2a3a2 ampar (Complex from Rattus norvegicus)
- 5b2 fab (19 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 3 (100 kDa, Protein from Rattus norvegicus)
- A'-c' auxiliary proteins (13 kDa, Protein from Rattus norvegicus)
- 15f1 fab heavy chain (27 kDa, Protein from Mus musculus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Lbd-tmd layers of native tri-heteromeric a1a2a3a2 ampar (Complex from Rattus norvegicus)
- 11b8 scfv (27 kDa, Protein from Mus musculus)
- Native glua1/glua2/glua3/glua2 complex bound with mpqx (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 15f1 fab light chain (25 kDa, Protein from Mus musculus)
Zhao Y, Chen S, Swensen AC, Qian WJ, Gouaux E
Science (2019) 364 pp. 355-362 [ Pubmed: 30975770 DOI: doi:10.1126/science.aaw8250 ]