Resolution: 5.63 Å
EM Method: Single-particle
Fitted PDBs: 8hwl
Q-score: 0.062
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Pyruvate carboxylase (Complex from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase in apo state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wta
Q-score: 0.265
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wtb
Q-score: 0.313
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7wtc
Q-score: 0.216
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wtd
Q-score: 0.226
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wte
Q-score: 0.36
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- Pc (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)