SARS-CoV-2 spike trimer (6P) in complex with two H18 and two R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Sars-cov-2 spike trimer (6p) in complex with two h18 and two r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex from Homo sapiens)
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with three h18 and three r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated)
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with three h18 and three r1-32 fabs (one rbd rotated) (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex from Homo sapiens)
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 S1 in complex with H18 and R1-32 Fab
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Sars-cov-2 s1 in complex with h18 and r1-32 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex from Homo sapiens)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Dimer of sars-cov-2 s1 in complex with h18 and r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex from Homo sapiens)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
Spike_GSAS_6P protomer RBD domain bound with R1-32 Fab and ACE2 with 3:3:3 ratio
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 7ydi
Q-score: 0.296
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- R1-32 fab (Complex)
- Heavy chain of r1-32 (23 kDa, Protein from Homo sapiens)
- Light chain of r1-32 (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 s-gsas/6p spike trimer (Complex from Homo sapiens)
- Ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s-gsas/6p spike trimer bound to r1-32 fab with 3:1 ratio (Complex from Homo sapiens)
Spike_GSAS_6P and R1-32 Fab with 3to1 ratio
Resolution: 4.75 Å
EM Method: Single-particle
Fitted PDBs: 7ydy
Q-score: 0.151
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s-gsas/6p spike trimer bound to r1-32 fab with 3:1 ratio (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R1-32 fab (Complex)
- Sars-cov-2 s-gsas/6p spike trimer (Complex from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-COV-2 Spike_GSAS_6P bound with two R1-32 Fabs
Resolution: 6.75 Å
EM Method: Single-particle
Fitted PDBs: 7ye5
Q-score: 0.029
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s-gsas/6p spike trimer (Complex from Homo sapiens)
- Sars-cov-2 s-gsas/6p spike trimer bound with r1-32 fab with 3:2 ratio (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-COV-2 Spike_GSAS_6P bound with three R1-32 Fabs
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7ye9
Q-score: 0.17
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike_gsas_6p (Complex from Homo sapiens)
- Sars-cov-2 spike_gsas_6p bound with three r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7yeg
Q-score: 0.149
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ace2 (Complex from Homo sapiens)
- Sars-cov-2 spike_gsas_6p (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 spike_gsas_6p bound with three r1-32 fabs and three ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Fabs (Complex)