ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8pjk
Q-score: 0.611
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- St171-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{h}-1,4-benzoxazin-3-one (372 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8pkm
Q-score: 0.468
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone (393 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Befiradol-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7w0l
Q-score: 0.427
Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F
Nat Struct Mol Biol (2022) 29 pp. 688-697 [ Pubmed: 35817871 DOI: doi:10.1038/s41594-022-00797-5 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r,2s)-n-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide (525 Da, Ligand)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Gpcr-gi complex (Complex from Homo sapiens)
Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7w0m
Q-score: 0.364
Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F
Nat Struct Mol Biol (2022) 29 pp. 688-697 [ Pubmed: 35817871 DOI: doi:10.1038/s41594-022-00797-5 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r,2s)-n-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide (525 Da, Ligand)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of gpcr with gi (Complex from Homo sapiens)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Composite Map
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Monovalent darpin r2 (Complex from Synthetic construct)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (state 1) (464 kDa, Complex)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome-related coronavirus)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 2)
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (state 2) (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome-related coronavirus)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Consensus Map
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) 40 pp. 1845-1854 [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Focused Refinement
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) 40 pp. 1845-1854 [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)