SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Composite Map
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Monovalent darpin r2 (Complex from Synthetic construct)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (state 1) (464 kDa, Complex)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome-related coronavirus)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 2)
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (state 2) (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome-related coronavirus)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Consensus Map
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) 40 pp. 1845-1854 [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Focused Refinement
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zurcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Nat Biotechnol (2022) 40 pp. 1845-1854 [ Pubmed: 35864170 DOI: doi:10.1038/s41587-022-01382-3 ]
- Monovalent darpin r2 (Protein from synthetic construct)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Sars-cov-2 s 2p trimer in complex with monovalent darpin r2 (464 kDa, Complex)
- Monovalent darpin r2 (Complex from synthetic construct)
- Sars-cov-2 spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m3e
Q-score: 0.563
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 455-459 [ Pubmed: 34194040 DOI: doi:10.1038/s41586-021-03691-0 ]
- Phosphate ion (94 Da, Ligand)
- Extracellular calcium-sensing receptor (101 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- 2-chloro-6-[(2r)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile (408 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human extracellular calcium-sensing receptor complexed with negative allosteric modulator nps-2143 under high calcium high trp condition (200 MDa, Complex from Homo sapiens)
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7m3j
Q-score: 0.426
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 455-459 [ Pubmed: 34194040 DOI: doi:10.1038/s41586-021-03691-0 ]
- Phosphate ion (94 Da, Ligand)
- Extracellular calcium-sensing receptor (101 kDa, Protein from Homo sapiens)
- Inactive-state human extracellular calcium-sensing receptor complexed with negative allosteric modulator nps-2143 (200 MDa, Complex from Homo sapiens)
- 2-chloro-6-[(2r)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile (408 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)