Cryo-EM Analysis of AE1 Structure in 100 mM NaCl Buffer: Form1
To Be Published
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- H6pd (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Cryo-EM Analysis of AE1 Structure in 100 mM NaCl Buffer: Form2
To Be Published
- Ae1 (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Cryo-EM Analysis of AE1 Structure in 100 mM NaHCO3 Buffer: Form1
To Be Published
- Ae1 (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Carbonate ion (60 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Cryo-EM Analysis of AE1 Structure in 100 mM NaHCO3 Buffer: Form2
To Be Published
- Ae1 (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Cryo-EM Analysis of AE1 Structure in 100 mM NaHCO3 Buffer: Form3
To Be Published
- Ae1 (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Carbonate ion (60 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Structure of MmpL3 reconstituted into lipid nanodisc in the TMM bound state
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 7n6b
Q-score: 0.558
Su CC, Klenotic PA, Cui M, Lyu M, Morgan CE, Yu EW
PLoS Biol (2021) 19 pp. e3001370-e3001370 [ Pubmed: 34383749 DOI: doi:10.1371/journal.pbio.3001370 ]
CryoEM Structure of the PfFNT-inhibitor complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 6vqr
Q-score: 0.522
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 6vks
Q-score: 0.48
Lyu M, Moseng MA, Reimche JL, Holley CL, Dhulipala V, Su CC, Shafer WM, Yu EW
Mbio (2020) 11 [ DOI: doi:10.1128/mBio.00996-20 Pubmed: 32457251 ]
- (2r,4s)-2-[(1r)-1-{[(2r)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (351 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Efflux pump membrane transporter (112 kDa, Protein from Neisseria gonorrhoeae)
- Mtrd efflux pump (300 kDa, Complex from Neisseria gonorrhoeae)