5-HT1A-Gi in complex with compound (R)-IHCH-7179
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jt6
Q-score: 0.542
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S
Cell (2024) 187 pp. 2194-2208.e22 [ Pubmed: 38552625 DOI: doi:10.1016/j.cell.2024.02.034 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-(4-fluorophenyl)-4-[(7r)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one (377 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- 5-ht1a-gi in complex with compound (r)-ihch-7179 (Complex from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xjl
Q-score: 0.559
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Pgf2-alpha-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xjm
Q-score: 0.555
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Latanoprost acid-fp-minigq-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of FFAR2 complex bound with TUG-1375
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j22
Q-score: 0.463
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ Pubmed: 38191689 DOI: doi:10.1038/s41422-023-00914-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ffar2 complex bound with tug-1375 (Complex from Homo sapiens)
- Free fatty acid receptor 2 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2r,4r)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid (442 Da, Ligand)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Structure of R2 with 3'UTR and DNA in binding state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8ibw
Q-score: 0.385
Deng P, Tan SQ, Yang QY, Fu L, Wu Y, Zhu HZ, Sun L, Bao Z, Lin Y, Zhang QC, Wang H, Wang J, Liu JG
Cell (2023) 186 pp. 2865-2879.e20 [ DOI: doi:10.1016/j.cell.2023.05.032 Pubmed: 37301196 ]
- Reverse transcriptase-like protein (123 kDa, Protein from Bombyx mori)
- R2 complex (177 kDa, Complex from Bombyx mori)
- Dna (60-mer) (18 kDa, DNA from Bombyx mori)
- Zinc ion (65 Da, Ligand)
- 3'utr (16 kDa, RNA from Bombyx mori)
- Dna (60-mer) (18 kDa, DNA from Bombyx mori)
Structure of R2 with 3'UTR and DNA in unwinding state
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8ibx
Q-score: 0.385
Deng P, Tan SQ, Yang QY, Fu L, Wu Y, Zhu HZ, Sun L, Bao Z, Lin Y, Zhang QC, Wang H, Wang J, Liu JG
Cell (2023) 186 pp. 2865-2879.e20 [ DOI: doi:10.1016/j.cell.2023.05.032 Pubmed: 37301196 ]
- Reverse transcriptase-like protein (123 kDa, Protein from Bombyx mori)
- R2 complex (177 kDa, Complex from Bombyx mori)
- Dna (60-mer) (18 kDa, DNA from Bombyx mori)
- Zinc ion (65 Da, Ligand)
- 3'utr (16 kDa, RNA from Bombyx mori)
- Dna (60-mer) (18 kDa, DNA from Bombyx mori)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8iby
Q-score: 0.342
Deng P, Tan SQ, Yang QY, Fu L, Wu Y, Zhu HZ, Sun L, Bao Z, Lin Y, Zhang QC, Wang H, Wang J, Liu JG
Cell (2023) 186 pp. 2865-2879.e20 [ DOI: doi:10.1016/j.cell.2023.05.032 Pubmed: 37301196 ]
- Reverse transcriptase-like protein (123 kDa, Protein from Bombyx mori)
- 5'orf rna (72 kDa, RNA from Bombyx mori)
- R2 complex (177 kDa, Complex from Bombyx mori)
- Zinc ion (65 Da, Ligand)
Structure of R2 with 5'ORF and 3'UTR
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8ibz
Q-score: 0.435
Deng P, Tan SQ, Yang QY, Fu L, Wu Y, Zhu HZ, Sun L, Bao Z, Lin Y, Zhang QC, Wang H, Wang J, Liu JG
Cell (2023) 186 pp. 2865-2879.e20 [ DOI: doi:10.1016/j.cell.2023.05.032 Pubmed: 37301196 ]
- Reverse transcriptase-like protein (123 kDa, Protein from Bombyx mori)
- Zinc ion (65 Da, Ligand)
- R2 complex (177 kDa, Complex from Bombyx mori)
- 5orf-linker-3utr (65 kDa, RNA from Bombyx mori)
Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7fdv
Q-score: 0.528
Xu D, Li Y, Yang F, Sun CR, Pan J, Wang L, Chen ZP, Fang SC, Yao X, Hou WT, Zhou CZ, Chen Y
Cell Rep (2022) 38 pp. 110298-110298 [ DOI: doi:10.1016/j.celrep.2022.110298 Pubmed: 35081353 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- The complex of human abcg1 with cholesterol and atp (152 kDa, Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 1 (75 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(e,2s,3r)-2-(hexadecanoylamino)-3-oxidanyl-octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate (703 Da, Ligand)
Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex.
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 7bz2
Q-score: 0.477
Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C
Cell Discov (2020) 6 pp. 45-45 [ DOI: doi:10.1038/s41421-020-0176-9 Pubmed: 32655881 ]
- Beta2 adrenergic receptor (42 kDa, Protein from Homo sapiens)
- Nb35 nanobody (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Beta2 adrenergic receptor-gs trimer complex with formoterol (151 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
- ~{n}-[5-[(1~{r})-2-[[(2~{r})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide (344 Da, Ligand)