Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8jzx
Q-score: 0.572
Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, Zhang S, Delacretaz M, Koren A, Hopp AK, Dvorak V, Kubicek S, Aletaha D, Yang M, Rebsamen M, Heinz LX, Superti-Furga G
Nat Commun (2023) 14 pp. 6626-6626 [ DOI: doi:10.1038/s41467-023-42070-3 Pubmed: 37863876 ]
- 2-(4-ethoxyphenyl)-n-[3-[(2r)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide (431 Da, Ligand)
- Lysosomal transporter,alfa tag,lysosomal transporter (62 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Endolysosomal transporter (Cellular component from Homo sapiens)
Active state CI from Q10-NADH dataset, Subclass 2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7w0y
Q-score: 0.523
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (12 kDa, Protein from pig)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-b18 (15 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from pig)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Deactive state CI from Rotenone-NADH dataset, Subclass 2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w2l
Q-score: 0.57
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Complex i-aggg (8 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-sgdh (16 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Complex i-b12 (9 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Complex i-kfyi (4 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
Active state CI from DQ-NADH dataset, Subclass 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w2r
Q-score: 0.597
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Active state CI from DQ-NADH dataset, Subclass 2
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7w2u
Q-score: 0.638
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Active state CI from DQ-NADH dataset, Subclass 3
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7w2y
Q-score: 0.626
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (9 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (16 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Deactive state CI from DQ-NADH dataset, Subclass 1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7w31
Q-score: 0.509
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Complex i-aggg (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-sgdh (16 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Complex i-b12 (9 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Deactive state CI from DQ-NADH dataset, Subclass 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w32
Q-score: 0.588
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Complex i-aggg (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-sgdh (16 kDa, Protein from pig)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Complex i-b12 (9 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Deactive state CI from DQ-NADH dataset, Subclass 3
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w35
Q-score: 0.559
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Complex i-aggg (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-sgdh (16 kDa, Protein from pig)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Complex i-b12 (9 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)
Active state CI from Q1-NADH dataset, Subclass 1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7w4c
Q-score: 0.622
Gu J, Liu T, Guo R, Zhang L, Yang M
Nat Struct Mol Biol (2022) 29 pp. 172-182 [ Pubmed: 35145322 DOI: doi:10.1038/s41594-022-00722-w ]
- Complex i-aggg (8 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (15 kDa, Protein from pig)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from pig)
- Complex i-b17 (15 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (23 kDa, Protein from pig)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Complex i subunit b13 (12 kDa, Protein from pig)
- Coenzyme q10, (2z,6e,10z,14e,18e,22e,26z)-isomer (863 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (17 kDa, Protein from pig)
- Nadh dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial (38 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (10 kDa, Protein from pig)
- Magnesium ion (24 Da, Ligand)
- Acyl carrier protein (10 kDa, Protein from pig)
- Complex i-b16.6 (16 kDa, Protein from pig)
- Complex i-49kd (49 kDa, Protein from pig)
- Complex i-30kd (24 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from pig)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Complex i-sgdh (16 kDa, Protein from pig)
- Complex i-b14.5a (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (36 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (47 kDa, Protein from pig)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (12 kDa, Protein from Pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (18 kDa, Protein from pig)
- Complex i-b12 (9 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from pig)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from pig)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Ubiquinone-1 (250 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (20 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (13 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 3 (12 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (19 kDa, Protein from pig)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (5 kDa, Protein from pig)
- Respiratory complex i (Complex from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (9 kDa, Protein from pig)
- Iron/sulfur cluster (351 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (14 kDa, Protein from pig)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (14 kDa, Protein from pig)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (75 kDa, Protein from pig)
- Complex i-9kd (5 kDa, Protein from pig)