Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ti1
Q-score: 0.419
Driggers CM, Kuo YY, Zhu P, ElSheikh A, Shyng SL
Nat Commun (2024) 15 pp. 2502-2502 [ Pubmed: 38509107 DOI: doi:10.1038/s41467-024-46751-5 ]
- Water (18 Da, Ligand)
- Kir6.2-q52r/sur1 open channel (880 kDa, Complex from Rattus norvegicus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Sur1 (177 kDa, Protein from Mesocricetus auratus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ti2
Q-score: 0.394
Driggers CM, Kuo YY, Zhu P, ElSheikh A, Shyng SL
Nat Commun (2024) 15 pp. 2502-2502 [ Pubmed: 38509107 DOI: doi:10.1038/s41467-024-46751-5 ]
- Water (18 Da, Ligand)
- Kir6.2-q52r/sur1 open channel (880 kDa, Complex from Rattus norvegicus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Sur1 (177 kDa, Protein from Mesocricetus auratus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7tys
Q-score: 0.478
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Repaglinide (452 Da, Ligand)
- Katp-rpg-atp-ctdup (Complex from Cricetus cricetus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Kir6.2 (Complex from Cricetus cricetus)
- Potassium ion (39 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
- (9r,12r)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate (481 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tyt
Q-score: 0.457
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Repaglinide (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Katp-rpg-atp-ctddown (Complex from Cricetus cricetus)
- Kir6.2 (Complex from Cricetus cricetus)
- Potassium ion (39 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7u1q
Q-score: 0.397
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Repaglinide (452 Da, Ligand)
- Katp-rpg-atp-sur1-in (Complex from Cricetus cricetus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Kir6.2 (Complex from Cricetus cricetus)
- Potassium ion (39 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7u1s
Q-score: 0.404
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Repaglinide (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Katp-rpg-atp-sur-out (Complex from Cricetus cricetus)
- Kir6.2 (Complex from Cricetus cricetus)
- Potassium ion (39 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7u24
Q-score: 0.452
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Katp-gbc-atp-ctdup (Complex from Cricetus cricetus)
- Kir6.2 (Complex from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7u2x
Q-score: 0.389
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ DOI: doi:10.1016/j.jmb.2022.167789 Pubmed: 35964676 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Katp-gbc-atp-ctdup (Complex from Cricetus cricetus)
- Kir6.2 (Complex from Cricetus cricetus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mit
Q-score: 0.51
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL
PNAS (2021) 118 [ Pubmed: 34711681 DOI: doi:10.1073/pnas.2109441118 ]
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 8 (48 kDa, Protein from Rattus norvegicus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Vascular katp channel: kir6.1 sur2b propeller-like conformation 1 (889 kDa, Complex from Rattus norvegicus)