Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 9dbk
Q-score: 0.41
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8), class I
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9dbl
Q-score: 0.399
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8), class II
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9dbm
Q-score: 0.396
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 9dbn
Q-score: 0.416
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Beta/omega-theraphotoxin-tp1a (Complex from Thrixopelma pruriens)
- Beta/omega-theraphotoxin-tp1a (3 kDa, Protein from Thrixopelma pruriens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- Sodium channel protein type 10 subunit alpha in complex with beta/omega-theraphotoxin-tp1a (Complex)
Mycobacterium tuberculosis EFPA antiparallel dimer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9bii
Q-score: 0.564
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
BRD-8000.3 bound EFPA transporter of Mycobacterium tuberculosis
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 9bin
Q-score: 0.488
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- (1s,3s)-n-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxamide (401 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
BRD-9327 bound EFPA transporter of Mycobacterium tuberculosis
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9biq
Q-score: 0.544
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- N-(7-benzoyl-2,3-dihydro-1,4-benzodioxin-6-yl)-2-bromobenzamide (438 Da, Ligand)
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
Cryo-EM structure of the light-driven sodium-pumping rhodopsin KR2
To Be Published
- Sodium pumping rhodopsin (31 kDa, Protein from Dokdonia eikasta)
- Oleic acid (282 Da, Ligand)
- Retinal (284 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Eicosane (282 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium-pumping rhodopsin (150 kDa, Complex from Dokdonia eikasta)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
Arabidopsis thaliana R2T complex
Palacios-Abella A, Lopez-Perrote A, Fonseca S, Urbez C, Rubio V, Boskovic J, Llorca O, Alabadi D
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- At1g56440 (59 kDa, Protein from Arabidopsis thaliana)
- Atr2t complex (700 kDa, Complex from Arabidopsis thaliana)
- Ruvb-like helicase (54 kDa, Protein from Arabidopsis thaliana)
- Ruvb-like protein 1 (53 kDa, Protein from Arabidopsis thaliana)
EAAT3 in 200 mM NaCl and 10 mM R-2-hydroxyglutarate buffer at OFS.
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.05.611541 Pubmed: 39282329 ]