Band 3-Glycophorin A complex, outward facing
Resolution: 2.35 Å
EM Method: Single-particle
Fitted PDBs: 7uz3
Q-score: 0.701
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Water (18 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Band 3 anion exchanger complexed with glycophorin a, in outward facing state. (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Band 3-I-TM local refinement from erythrocyte ankyrin-1 complex consensus reconstruction
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7v07
Q-score: 0.604
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Ankyrin complex mixture purified from digitonin-solubilized erythrocyte ghost membranes (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Consensus refinement of human erythrocyte ankyrin-1 complex (Composite map)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7v0k
Q-score: 0.703
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Protein 4.2 (77 kDa, Protein from Homo sapiens)
- Ankyrin-1 (206 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Band 3 anion exchanger complexed with glycophorin a, in outward facing state (Complex from Homo sapiens)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ammonium transporter rh type a (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Blood group rh(ce) polypeptide (45 kDa, Protein from Homo sapiens)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Local refinement of Band 3-II transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7v19
Q-score: 0.484
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Erythrocyte ankyrin-1 complex (Complex from Homo sapiens)
Local refinement of Band 3-I transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8crq
Q-score: 0.52
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Erythrocyte ankyrin-1 complex (Complex from Homo sapiens)
Local refinement of Band 3-III transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8crr
Q-score: 0.574
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Erythrocyte ankyrin-1 complex (Complex from Homo sapiens)
Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8cs9
Q-score: 0.588
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Ankyrin-1 (206 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Class 1 of erythrocyte ankyrin complex (composite map) (Complex from Homo sapiens)
- Glycophorin-b (9 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ammonium transporter rh type a (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein 4.2 (77 kDa, Protein from Homo sapiens)
- Blood group rh(ce) polypeptide (45 kDa, Protein from Homo sapiens)
Local refinement of band3-I transmembrane region from class 2 of erythrocyte ankyrin-1 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ct3
Q-score: 0.432
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Class 1 of erythrocyte ankyrin complex (composite map) (Complex from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Class 2 of erythrocyte ankyrin-1 complex (Composite map)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8cte
Q-score: 0.562
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB
Nat Struct Mol Biol (2022) 29 pp. 706-718 [ DOI: doi:10.1038/s41594-022-00792-w Pubmed: 35835865 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Aquaporin-1 (28 kDa, Protein from human)
- Band 3 anion transport protein (101 kDa, Protein from human)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Ankyrin-1 (206 kDa, Protein from human)
- Digitonin (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Class 1 of erythrocyte ankyrin complex (composite map) (Complex from Homo sapiens)
- Glycophorin-a (16 kDa, Protein from human)
- Blood group rh(ce) polypeptide (45 kDa, Protein from human)
- Protein 4.2 (77 kDa, Protein from human)
- Ammonium transporter rh type a (44 kDa, Protein from human)
Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 7sin
Q-score: 0.19
Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR
PNAS (2021) 118 [ Pubmed: 34916296 DOI: doi:10.1073/pnas.2115849118 ]