Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 9dbk
Q-score: 0.41
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8), class I
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9dbl
Q-score: 0.399
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Full-length apo human voltage-gated sodium channel 1.8 (NaV1.8), class II
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9dbm
Q-score: 0.396
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 9dbn
Q-score: 0.416
Neumann B, McCarthy S, Gonen S
Nat Commun (2025) 16 pp. 1459-1459 [ DOI: doi:10.1038/s41467-024-55764-z Pubmed: 39920100 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (225 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (Complex from Homo sapiens)
- Beta/omega-theraphotoxin-tp1a (Complex from Thrixopelma pruriens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Sodium channel protein type 10 subunit alpha in complex with beta/omega-theraphotoxin-tp1a (Complex)
- Beta/omega-theraphotoxin-tp1a (3 kDa, Protein from Thrixopelma pruriens)
Mycobacterium tuberculosis EFPA antiparallel dimer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9bii
Q-score: 0.564
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- Cholesterol hemisuccinate (486 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
BRD-8000.3 bound EFPA transporter of Mycobacterium tuberculosis
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 9bin
Q-score: 0.488
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- (1s,3s)-n-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxamide (401 Da, Ligand)
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
BRD-9327 bound EFPA transporter of Mycobacterium tuberculosis
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9biq
Q-score: 0.544
Khandelwal NK, Gupta M, Stroud RM
To Be Published
- N-(7-benzoyl-2,3-dihydro-1,4-benzodioxin-6-yl)-2-bromobenzamide (438 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{r})-3-[[(2~{r})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-2-hexadecanoyloxy-propyl] octadecanoate (751 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (66 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Efpa (66 kDa, Complex from Mycobacterium tuberculosis)
Cryo-EM structure of the light-driven sodium-pumping rhodopsin KR2
To Be Published
- Water (18 Da, Ligand)
- Retinal (284 Da, Ligand)
- Eicosane (282 Da, Ligand)
- Sodium pumping rhodopsin (31 kDa, Protein from Dokdonia eikasta)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Sodium-pumping rhodopsin (150 kDa, Complex from Dokdonia eikasta)
EAAT3 in 200 mM NaCl and 10 mM R-2-hydroxyglutarate buffer at OFS.
bioRxiv (2024) [ Pubmed: 39282329 DOI: doi:10.1101/2024.09.05.611541 ]
Resolution: 3.08 Å
EM Method: Helical reconstruction
Fitted PDBs: 9gas
Q-score: 0.531
Chenavier F, Zarkadas E, Freslon LL, Stelfox AJ, Schoehn G, Ruigrok RWH, Ballandras-Colas A, Crepin T
Nucleic Acids Res (2025) 53 [ DOI: doi:10.1093/nar/gkae1211 Pubmed: 39673795 ]
- Complex np-rna (Complex)
- Nucleoprotein (56 kDa, Protein from Influenza A virus)
- Rna (Complex from synthetic construct)
- 2-[3,6-bis(oxidanylidene)-4,5-dihydroxanthen-9-yl]-4-[3-[(2r)-2-oxidanylpropoxy]propylcarbamoyl]benzoic acid (493 Da, Ligand)
- Rna (5'-p(uc)9-fam3') (5 kDa, RNA from synthetic construct)
- Nucleoprotein (Complex from Influenza A virus)