Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8y1v
Q-score: 0.333
To Be Published
- Isoform 6 of glutamate receptor ionotropic, nmda 1 (97 kDa, Protein from Homo sapiens)
- N-methyl-d-aspartate receptors (400 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (99 kDa, Protein from Homo sapiens)
- (2~{r},3~{s},4~{s},5~{r},6~{r})-2-(hydroxymethyl)-6-[(2~{s})-2-methyl-4-[(1~{r},2~{r},4~{s},6~{s},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s},18~{r})-7,9,13,18-tetramethyl-16-oxidanyl-5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan-6-yl]butoxy]oxane-3,4,5-triol (592 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8xn1
Q-score: 0.482
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc transporter 3 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Probable proton-coupled zinc antiporter slc30a3 (42 kDa, Protein from Homo sapiens)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8foi
Q-score: 0.564
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Native gabaa receptor isolated from mouse brain containing two alpha1 subunits, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Light chain of 8e3-fab (23 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- N-octane (114 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8g4x
Q-score: 0.504
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8g5f
Q-score: 0.491
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8g5g
Q-score: 0.435
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- Zolpidem (307 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, zolpidem, and endogenous neurosteroid (350 kDa, Complex from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8g5h
Q-score: 0.477
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- Zolpidem (307 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, zolpidem, and endogenous neurosteroid (350 kDa, Complex from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Structure of hSLC19A1+3'3'-CDA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7xq0
Q-score: 0.558
Zhang Q, Zhang X, Zhu Y, Sun P, Zhang L, Ma J, Zhang Y, Zeng L, Nie X, Gao Y, Li Z, Liu S, Lou J, Gao A, Zhang L, Gao P
Nature (2022) 612 pp. 170-176 [ DOI: doi:10.1038/s41586-022-05452-z Pubmed: 36265513 ]
- Reduced folate transporter (60 kDa, Protein from Homo sapiens)
- (2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide (658 Da, Ligand)
- Slc19a1+3'3'-cda (Complex from Homo sapiens)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7eor
Q-score: 0.284
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ DOI: doi:10.1016/j.neuron.2021.05.031 Pubmed: 34186027 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{r},2~{r})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one (360 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in the glycine/glutamate/gne-6901 bound state (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901/9-AA bound state
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7eou
Q-score: 0.259
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron (2021) 109 pp. 2443-2456.e5 [ DOI: doi:10.1016/j.neuron.2021.05.031 Pubmed: 34186027 ]
- Glutamate receptor ionotropic, nmda 2a (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{r},2~{r})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one (360 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 9-aminoacridine (195 Da, Ligand)
- Structure of the human glun1/glun2a nmda receptor in the glycine/glutamate/gne-6901/9-aa bound state (Complex from Homo sapiens)