Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8e4y
Q-score: 0.502
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H
Nat Struct Mol Biol (2023) 30 pp. 22-30 [ Pubmed: 36522428 DOI: doi:10.1038/s41594-022-00884-7 ]
- [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2-oxohexadecyl)sulfanyl]ethyl}amino)propyl]amino}butyl dihydrogen diphosphate (non-preferred name) (1 kDa, Ligand)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (410 Da, Ligand)
- Glycerol-3-phosphate acyltransferase 1, mitochondrial (86 kDa, Protein from Homo sapiens)
- Glycerol-3-phosphate acyltransferase 1 (86 kDa, Complex from Homo sapiens)
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8e50
Q-score: 0.444
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H
Nat Struct Mol Biol (2023) 30 pp. 22-30 [ Pubmed: 36522428 DOI: doi:10.1038/s41594-022-00884-7 ]
- Coenzyme a (767 Da, Ligand)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (410 Da, Ligand)
- Glycerol-3-phosphate acyltransferase 1, mitochondrial (86 kDa, Protein from Homo sapiens)
- Glycerol-3-phosphate acyltransferase 1 (86 kDa, Complex from Homo sapiens)
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6nzu
Q-score: 0.546
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nat Commun (2019) 10 pp. 2210-2210 [ Pubmed: 31101807 DOI: doi:10.1038/s41467-019-09989-y ]
- The human frataxin-bound iron-sulfur cluster assembly complex (186 kDa, Complex from Homo sapiens)
- Cysteine desulfurase, mitochondrial (44 kDa, Protein from Homo sapiens)
- Acyl carrier protein (8 kDa, Protein from Escherichia coli)
- Zinc ion (65 Da, Ligand)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Frataxin, mitochondrial (14 kDa, Protein from Homo sapiens)
- Lyr motif-containing protein 4 (10 kDa, Protein from Homo sapiens)
- Iron-sulfur cluster assembly enzyme iscu, mitochondrial (13 kDa, Protein from Homo sapiens)