Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz2
Q-score: 0.422
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (1r,2s,3s,4r,5r,9s,11s,12s,14r)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) (301 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vfs
Q-score: 0.533
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y
Cell Rep (2021) 37 pp. 109931-109931 [ DOI: doi:10.1016/j.celrep.2021.109931 Pubmed: 34731621 ]
- Hexadecane (226 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Cav2.2-alpha2delta1-beta1 complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7vfv
Q-score: 0.49
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y
Cell Rep (2021) 37 pp. 109931-109931 [ DOI: doi:10.1016/j.celrep.2021.109931 Pubmed: 34731621 ]
- Hexadecane (226 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(2~{s})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide (599 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Cav2.2-alpha2delta1-beta1 complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vfw
Q-score: 0.407
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y
Cell Rep (2021) 37 pp. 109931-109931 [ DOI: doi:10.1016/j.celrep.2021.109931 Pubmed: 34731621 ]
- Hexadecane (226 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Cav2.2-alpha2delta1-beta1 complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole (424 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7mdx
Q-score: 0.363
Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y, Liao M
Nat Commun (2021) 12 pp. 4687- [ DOI: doi:10.1038/s41467-021-24965-1 ]
- Lipo-releasing system transmembrane protein lolc (e.c.3.6.3.-), lipoprotein-releasing system transmembrane protein (e.c.3.6.3.-), lipoprotein-releasing system atp-binding protein lold (e.c.7.6.2.-), triacyl-lipoprotein (130 MDa, Complex from Escherichia coli)
- Lipoprotein-releasing system transmembrane protein lole (44 kDa, Protein from Escherichia coli)
- Lipoprotein-releasing system transmembrane protein lolc (42 kDa, Protein from Escherichia coli)
- Pentadecanoic acid (242 Da, Ligand)
- Lipoprotein-releasing system atp-binding protein lold (23 kDa, Protein from Escherichia coli)
- Triacyl-lipoprotein (492 Da, Protein from Escherichia coli)
- (2r)-2-(tridecanoyloxy)propyl hexadecanoate (526 Da, Ligand)
Nucleotide-free Cryo-EM Structure of E.coli LptB2FGC
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6mi7
Q-score: 0.417
Nature (2019) 567 pp. 486-490 [ DOI: doi:10.1038/s41586-019-1025-6 Pubmed: 30894744 ]
- Lipopolysaccharide export system atp-binding protein lptb (28 kDa, Protein from Escherichia coli (strain K12))
- Lptb2fgc (Complex from Escherichia coli)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Lipopolysaccharide export system protein lptc (23 kDa, Protein from Escherichia coli (strain K12))
- Lipopolysaccharide export system permease protein lptg (39 kDa, Protein from Escherichia coli (strain K12))
- Lipopolysaccharide export system permease protein lptf (40 kDa, Protein from Escherichia coli (strain K12))