Mediator-RNA Polymerase II Pre-Initiation Complex Delta Mediator Tail (Focused Refinement)
Resolution: 15.3 Å
EM Method: Single-particle
Fitted PDBs: 5sva
Q-score: 0.049
Robinson PJ, Trnka MJ, Bushnell DA, Davis RE, Mattei PJ, Burlingame AL, Kornberg RD
Cell (2016) 166 pp. 1411-1422.e16 [ Pubmed: 27610567 DOI: doi:10.1016/j.cell.2016.08.050 ]
- Dna-directed rna polymerases i, ii, and iii subunit rpabc 2 (Protein from yeast)
- Transcription initiation factor iif subunit alpha (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 20 (Protein from yeast)
- Mediator-rna polymerase ii pre-initiation complex delta mediator tail (1 MDa, Complex)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc 1 (Protein from yeast)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc 4 (Protein from yeast)
- Transcription factor tfiie subunit tfa2 (Protein from Saccharomyces cerevisiae)
- Mediator of rna polymerase ii transcription subunit 31 (Protein from yeast)
- Rna polymerase ii transcription factor b subunit 3 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 18 (Protein from yeast)
- Dna repair helicase rad3 (Protein from yeast)
- Transcription initiation factor iif subunit beta (Protein from yeast)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 22 (Protein from yeast)
- Transcription initiation factor iib (Protein from Saccharomyces cerevisiae)
- Transcription initiation factor iia subunit 2 (Protein from Saccharomyces cerevisiae)
- Cyclin ccl1 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 11 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 17 (Protein from yeast)
- Transcription initiation factor iia large subunit (Protein from Saccharomyces cerevisiae)
- Mediator of rna polymerase ii transcription subunit 1 (Protein from yeast)
- Rna polymerase ii transcription factor b subunit 1 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb2 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb7 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 6 (Protein from yeast)
- Transcription factor tfiie subunit tfa1 (Protein from Saccharomyces cerevisiae)
- Serine/threonine-protein kinase kin28 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb4 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 10 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 14 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 21 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb9 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 4 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 19 (Protein from yeast)
- Rna polymerase ii transcription factor b subunit 2 (Protein from yeast)
- Transcription initiation factor iif subunit gamma (Protein from yeast)
- Rna polymerase ii transcription factor b subunit 4 (Protein from yeast)
- Suppressor of stem-loop protein 1 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 7 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb3 (Protein from yeast)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc 5 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb11 (Protein from yeast)
- Tata-box-binding protein (Protein from Saccharomyces cerevisiae)
- Rna polymerase ii transcription factor b subunit 5 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 8 (Protein from yeast)
- Mediator of rna polymerase ii transcription subunit 9 (Protein from yeast)
- 108 bp his4 promoter fragment (DNA from Saccharomyces cerevisiae)
- Dna repair helicase rad25 (Protein from yeast)
- Dna-directed rna polymerase ii subunit rpb1 (Protein from yeast)
Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5
Kassube SA, Jinek M, Fang J, Tsutakawa S, Nogales E
Nat Struct Mol Biol (2013) 20 pp. 892-899 [ DOI: doi:10.1038/nsmb.2596 Pubmed: 23748380 ]
- Recql5 (69 kDa, Protein from Homo sapiens)
- Human pol ii in complex with artificial transcription bubble and recql5 (615 kDa, Sample)
- Non-template strand (13 kDa, DNA from unidentified)
- Template strand (8 kDa, DNA from unidentified)
- Transcription bubble rna strand (6 kDa, RNA from unidentified)
- Rna polymerase ii (517 kDa, Protein from Homo sapiens)
Structural visualization of key steps in human transcription initiation
He Y, Fang J, Taatjes DJ, Nogales E
Nature (2013) 495 pp. 481-486 [ Pubmed: 23446344 DOI: doi:10.1038/nature11991 ]
- General transcription factor iia (54 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (38 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii (550 kDa, Protein from Homo sapiens)
- General transcription factor iib (35 kDa, Protein from Homo sapiens)
- Core promoter dna (55 kDa, DNA from Homo sapiens)
- Tbp-tfiia-tfiib-dna-pol ii (close) (730 kDa, Sample)
Structural visualization of key steps in human transcription initiation
He Y, Fang J, Taatjes DJ, Nogales E
Nature (2013) 495 pp. 481-486 [ Pubmed: 23446344 DOI: doi:10.1038/nature11991 ]
- General transcription factor iia (54 kDa, Protein from Homo sapiens)
- General transcription factor iif (87 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (38 kDa, Protein from Homo sapiens)
- Tbp-tfiia-tfiib-dna-pol ii-tfiif (close) (820 kDa, Sample)
- Dna-directed rna polymerase ii (550 kDa, Protein from Homo sapiens)
- General transcription factor iib (35 kDa, Protein from Homo sapiens)
- Core promoter dna (55 kDa, DNA from Homo sapiens)
Structural visualization of key steps in human transcription initiation
He Y, Fang J, Taatjes DJ, Nogales E
Nature (2013) 495 pp. 481-486 [ Pubmed: 23446344 DOI: doi:10.1038/nature11991 ]
- General transcription factor iia (54 kDa, Protein from Homo sapiens)
- General transcription factor iif (87 kDa, Protein from Homo sapiens)
- Core promoter dna (54 kDa, Macromolecule from Homo sapiens)
- Tata-box-binding protein (38 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii (550 kDa, Protein from Homo sapiens)
- General transcription factor iie (82 kDa, Protein from Homo sapiens)
- General transcription factor iib (35 kDa, Protein from Homo sapiens)
- Tbp-tfiia-tfiib-dna-pol ii-tfiif-tfiie (open) (900 kDa, Sample)
Structural visualization of key steps in human transcription initiation
He Y, Fang J, Taatjes DJ, Nogales E
Nature (2013) 495 pp. 481-486 [ DOI: doi:10.1038/nature11991 Pubmed: 23446344 ]
- General transcription factor iie (82 kDa, Protein from Homo sapiens)
- General transcription factor iif (87 kDa, Protein from Homo sapiens)
- Tbp-tfiia-tfiib-dna-pol ii-tfiif-tfiie-tfiih (close) (1 MDa, Sample)
- General transcription factor iib (35 kDa, Protein from Homo sapiens)
- General transcription factor iia (54 kDa, Protein from Homo sapiens)
- Core promoter dna (55 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase ii (550 kDa, Protein from Homo sapiens)
- General transcription factor iih (450 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (38 kDa, Protein from Homo sapiens)