Structure of the kinase lobe of human CDK8 kinase module
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8tq2
Q-score: 0.46
Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL
Mol Cell (2024) 84 pp. 3932-3949.e10 [ Pubmed: 39321804 DOI: doi:10.1016/j.molcel.2024.09.001 ]
- Cyclin-dependent kinase 8 (53 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 12 (243 kDa, Protein from Homo sapiens)
- Cyclin-c (33 kDa, Protein from Homo sapiens)
- Human cdk8 kinase module (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 13 (239 kDa, Protein from Homo sapiens)
Structure of the human CDK8 kinase module
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8tqc
Q-score: 0.302
Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL
Mol Cell (2024) 84 pp. 3932-3949.e10 [ Pubmed: 39321804 DOI: doi:10.1016/j.molcel.2024.09.001 ]
- Cyclin-dependent kinase 8 (53 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 12 (243 kDa, Protein from Homo sapiens)
- Cyclin-c (33 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Human cdk8 kinase module (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 13 (239 kDa, Protein from Homo sapiens)
Structure of human transcriptional Mediator complex
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 8tqw
Q-score: 0.111
Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL
Mol Cell (2024) 84 pp. 3932-3949.e10 [ Pubmed: 39321804 DOI: doi:10.1016/j.molcel.2024.09.001 ]
- The human transcriptional mediator complex (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 8 (53 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 16 (96 kDa, Protein from Homo sapiens)
- Cyclin-c (33 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)
- Unknown chain (1 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 19 (26 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 12 (243 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 13 (239 kDa, Protein from Homo sapiens)
The IDRc bound human core Mediator complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8trh
Q-score: 0.317
Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL
Mol Cell (2024) 84 pp. 3932-3949.e10 [ Pubmed: 39321804 DOI: doi:10.1016/j.molcel.2024.09.001 ]
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
- The idrc bound human core mediator complex (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 16 (96 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)
- Unknown chain (1 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 19 (26 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 13 (239 kDa, Protein from Homo sapiens)
Structure of kinase and Central lobes of yeast CKM
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kpv
Q-score: 0.425
Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL
Sci Adv (2021) 7 [ Pubmed: 33523904 DOI: doi:10.1126/sciadv.abd4484 ]
- Rna polymerase ii holoenzyme cyclin-like subunit (37 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mediator of rna polymerase ii transcription subunit 13 (160 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mediator of rna polymerase ii transcription subunit 12 (167 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Meiotic mrna stability protein kinase ssn3 (62 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Yeast cdk8 complex (430 kDa, Complex from Saccharomyces cerevisiae S288C)
Structure of the H-lobe of yeast CKM
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 7kpw
Q-score: 0.256
Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL
Sci Adv (2021) 7 [ Pubmed: 33523904 DOI: doi:10.1126/sciadv.abd4484 ]
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7kpx
Q-score: 0.296
Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL
Sci Adv (2021) 7 [ Pubmed: 33523904 DOI: doi:10.1126/sciadv.abd4484 ]
- Mediator of rna polymerase ii transcription subunit 13 (160 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Rna polymerase ii holoenzyme cyclin-like subunit (41 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mediator of rna polymerase ii transcription subunit 12 (167 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Meiotic mrna stability protein kinase ssn3 (62 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Yeast cdk8 complex (430 kDa, Complex from Saccharomyces cerevisiae S288C)
Cryo-EM map of the Mediator-RNAPII complex
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 5u0s
Q-score: 0.123
Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ
Nature (2017) 544 pp. 196-201 [ Pubmed: 28241144 DOI: doi:10.1038/nature21393 ]
- Mediator complex subunit 17 (62 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb1 (194 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 11 (13 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 8 (23 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 4 (20 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 20 (22 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 7 (43 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb10 (8 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 22 (15 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 21 (15 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 18 (24 kDa, Protein from Schizosaccharomyces pombe)
- Complex of mediator and rnapii (1 MDa, Complex from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb11 (14 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 14 (105 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb12 (7 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb5 (23 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 19 (11 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 9 (13 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 10 (11 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb6 (15 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb2 (138 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb9 (13 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb3 (33 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb4 (15 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 31 (16 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb8 (14 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 6 (24 kDa, Protein from Schizosaccharomyces pombe)
- Rna polymerase ii subunit rpb7 (19 kDa, Protein from Schizosaccharomyces pombe)
- Mediator complex subunit 27 (31 kDa, Protein from Schizosaccharomyces pombe)