Human NEXT dimer - single protomer
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505-2518.e7 [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Rna 5prime hairpin u60 (Complex from synthetic construct)
- Zinc finger cchc domain-containing protein 8 (Protein from Homo sapiens)
- Rna 5prime hairpin u60 (RNA from synthetic construct)
- Rna-binding protein 7 (Protein from Homo sapiens)
- Human next dimer - single protomer (Complex)
- Exosome rna helicase mtr4 (Protein from Homo sapiens)
- Human next dimer - single protomer (Complex from Homo sapiens)
Human NEXT dimer in complex with the nuclear RNA exosome
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505-2518.e7 [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Zinc finger cchc domain-containing protein 8 (Protein from Homo sapiens)
- Nuclear nucleic acid-binding protein c1d (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (RNA from synthetic construct)
- Exosome complex component rrp46 (Protein from Homo sapiens)
- Human next dimer in complex with the nuclear rna exosome (Complex from Homo sapiens)
- Human next dimer in complex with the nuclear rna exosome (Complex)
- Exosome rna helicase mtr4 (Protein from Homo sapiens)
- M-phase phosphoprotein 6 (Protein from Homo sapiens)
- Exosome complex component mtr3 (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (Complex from synthetic construct)
- Exosome complex component rrp42 (Protein from Homo sapiens)
- Exosome complex component rrp45 (Protein from Homo sapiens)
- Exosome complex component rrp40 (Protein from Homo sapiens)
- Exosome complex component csl4 (Protein from Homo sapiens)
- Exosome component 10 (Protein from Homo sapiens)
- Rna-binding protein 7 (Protein from Homo sapiens)
- Exosome complex component rrp41 (Protein from Homo sapiens)
- Exosome complex exonuclease rrp44 (Protein from Homo sapiens)
- Exosome complex component rrp4 (Protein from Homo sapiens)
Human Nuclear exosome targeting (NEXT) complex homodimer bound to RNA (substrate 1)
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 7s7b
Q-score: 0.444
Cell (2022) 185 pp. 2132-2147.e26 [ DOI: doi:10.1016/j.cell.2022.04.016 Pubmed: 35688134 ]
- Rna-binding protein 7 (9 kDa, Protein from Homo sapiens)
- Zinc finger cchc domain-containing protein 8,zinc finger cchc domain-containing protein 8 (69 kDa, Protein from Homo sapiens)
- Human nuclear exosome targeting (next)-rna substrate 1 complex (Complex from Homo sapiens)
- Rna (46-mer) (14 kDa, RNA from synthetic construct)
- Exosome rna helicase mtr4 (118 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 7s7c
Q-score: 0.449
Cell (2022) 185 pp. 2132-2147.e26 [ Pubmed: 35688134 DOI: doi:10.1016/j.cell.2022.04.016 ]
- Rna (30-mer) (9 kDa, RNA from synthetic construct)
- Exosome rna helicase mtr4 (118 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Rna-binding protein 7 (9 kDa, Protein from Homo sapiens)
- Zinc finger cchc domain-containing protein 8 (69 kDa, Protein from Homo sapiens)
- Human nuclear exosome targeting (next) complex bound to rna (substrate 2) (Complex from Homo sapiens)