Human Amylin1 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7tyf
Q-score: 0.631
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human amylin1 receptor in complex with gs and rat amylin peptide (Complex)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7tyw
Q-score: 0.477
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Water (18 Da, Ligand)
- Calcitonin-1 (3 kDa, Protein from Salmo salar)
- Human amylin 1 receptor in complex with gs and salmon calcitonin peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
CryoEM structure of the apo-CGRP receptor in a detergent micelle
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7knt
Q-score: 0.39
Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2021) 372 [ DOI: doi:10.1126/science.abf7258 Pubmed: 33602864 ]
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- Apo cgrp receptor (Complex from Homo sapiens)
- Calcitonin gene-related peptide type 1 receptor (56 kDa, Protein from Homo sapiens)
CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7knu
Q-score: 0.351
Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2021) 372 [ Pubmed: 33602864 DOI: doi:10.1126/science.abf7258 ]
- Calcitonin gene-related peptide type 1 receptor (56 kDa, Protein from Homo sapiens)
- Cgrp receptor bound to cgrp and ramp1 (Complex)
- Calcitonin gene-related peptide 1 (Complex from Homo sapiens)
- Calcitonin gene-related peptide 1 (3 kDa, Protein from Homo sapiens)
- Cgrp receptor with ramp1 (Complex from Homo sapiens)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)