CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8ovj
Q-score: 0.63
Rajan KS, Aryal S, Hiregange DG, Bashan A, Madmoni H, Olami M, Doniger T, Cohen-Chalamish S, Pescher P, Taoka M, Nobe Y, Fedorenko A, Bose T, Zimermann E, Prina E, Aharon-Hefetz N, Pilpel Y, Isobe T, Unger R, Spath GF, Yonath A, Michaeli S
Cell Rep (2024) 43 pp. 114203-114203 [ Pubmed: 38722744 DOI: doi:10.1016/j.celrep.2024.114203 ]
- 40s ribosomal protein s5 (21 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l37a (10 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s19-like protein (18 kDa, Protein from Leishmania major strain Friedlin)
- Putative rna binding protein (25 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s4 (30 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l28 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s15 (17 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s21 (17 kDa, Protein from Leishmania major strain Friedlin)
- Potassium ion (39 Da, Ligand)
- Putative 40s ribosomal protein s16 (16 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l27 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l36 (11 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l30 (11 kDa, Protein from Leishmania major strain Friedlin)
- Water (18 Da, Ligand)
- Putative 60s ribosomal protein l35 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l39 (6 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l32 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l23a (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s18 (17 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein l14 (19 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l35a (16 kDa, Protein from Leishmania major strain Friedlin)
- Zinc ion (65 Da, Ligand)
- Putative 60s ribosomal protein l27a/l29 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l24 (14 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l34 (19 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s14 (15 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s26 (12 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l18 (22 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l7 (28 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l29 (8 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l26 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l19 (28 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l9 (21 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l21 (18 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s30 (7 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l5 (34 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l44 (12 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s23 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l2 (28 kDa, Protein from Leishmania major strain Friedlin)
- Sr2_chain_4 (59 kDa, RNA from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l13 (24 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s3 (24 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s24 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s11 (20 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s12 (15 kDa, Protein from Leishmania major strain Friedlin)
- Lsub_rrna_chain_2 (492 kDa, RNA from Leishmania major strain Friedlin)
- Lsua_rrna_chain_1 (577 kDa, RNA from Leishmania major strain Friedlin)
- Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein s29 (6 kDa, Protein from Leishmania major strain Friedlin)
- 5s_rrna_chain_8 (39 kDa, RNA from Leishmania major strain Friedlin)
- 60s ribosomal protein l11 (21 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s2 (28 kDa, Protein from Leishmania major strain Friedlin)
- E-site_trna_chain_s4 (6 kDa, RNA from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l17 (19 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l41 (4 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l22 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s10 (18 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l6 (21 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein s20 (13 kDa, Protein from Leishmania major strain Friedlin)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s25 (13 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s8 (24 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s7 (23 kDa, Protein from Leishmania major strain Friedlin)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l18a (20 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l1a (41 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s13 (17 kDa, Protein from Leishmania major strain Friedlin)
- Ribosomal protein l15 (24 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s3a (30 kDa, Protein from Leishmania major strain Friedlin)
- Sodium ion (22 Da, Ligand)
- Ssu_rrna_chain_s1 (710 kDa, RNA from Leishmania major strain Friedlin)
- 60s ribosomal protein l7a (29 kDa, Protein from Leishmania major strain Friedlin)
- Sr6_chain_6 (23 kDa, RNA from Leishmania major strain Friedlin)
- 5.8s_rrna_chain_7 (54 kDa, RNA from Leishmania major strain Friedlin)
- 80s ribosome from leishmania major (Complex from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s27-1 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l13a (25 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l38 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal subunit protein l31 (21 kDa, Protein from Leishmania major strain Friedlin)
- Ribosomal protein l37 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s15a (14 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s17 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s9 (22 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s6 (28 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l10 (24 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l3 (47 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l23 (14 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein sa (27 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s33 (9 kDa, Protein from Leishmania major strain Friedlin)
- Sr1_chain_3 (69 kDa, RNA from Leishmania major strain Friedlin)
- Sr4_chain_5 (43 kDa, RNA from Leishmania major strain Friedlin)
CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution: 2.46 Å
EM Method: Single-particle
Fitted PDBs: 8a98
Q-score: 0.653
Rajan KS, Aryal S, Hiregange DG, Bashan A, Madmoni H, Olami M, Doniger T, Cohen-Chalamish S, Pescher P, Taoka M, Nobe Y, Fedorenko A, Bose T, Zimermann E, Prina E, Aharon-Hefetz N, Pilpel Y, Isobe T, Unger R, Spath GF, Yonath A, Michaeli S
Cell Rep (2024) 43 pp. 114203-114203 [ Pubmed: 38722744 DOI: doi:10.1016/j.celrep.2024.114203 ]
- 40s ribosomal protein s5 (21 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l37a (10 kDa, Protein from Leishmania major strain Friedlin)
- 5.8s_rrna_chain_7 (54 kDa, RNA from Leishmania major strain Friedlin)
- Putative rna binding protein (25 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s4 (30 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l28 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s15 (17 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s21 (17 kDa, Protein from Leishmania major strain Friedlin)
- Potassium ion (39 Da, Ligand)
- Putative 40s ribosomal protein s16 (16 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l27 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l36 (11 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l30 (11 kDa, Protein from Leishmania major strain Friedlin)
- Water (18 Da, Ligand)
- Putative 60s ribosomal protein l35 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l39 (6 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l32 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l23a (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s18 (17 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein l14 (19 kDa, Protein from Leishmania major strain Friedlin)
- Small ribosomal subunit protein rack1 (34 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l35a (16 kDa, Protein from Leishmania major strain Friedlin)
- Zinc ion (65 Da, Ligand)
- Putative 60s ribosomal protein l27a/l29 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l24 (14 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l34 (19 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s26 (12 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l18 (22 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s14 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l7 (28 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l29 (8 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l26 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l19 (28 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l9 (21 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l21 (18 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s30 (7 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l5 (34 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l44 (12 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s23 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l2 (28 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s19-like protein (18 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s3 (24 kDa, Protein from Leishmania major strain Friedlin)
- Lsua_rrna_chain_1 (577 kDa, RNA from Leishmania major strain Friedlin)
- 40s ribosomal protein s24 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s11 (20 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s12 (15 kDa, Protein from Leishmania major strain Friedlin)
- Sr4_chain_5 (43 kDa, RNA from Leishmania major strain Friedlin)
- Putative ribosomal protein s29 (6 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s2 (28 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l11 (21 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l17 (19 kDa, Protein from Leishmania major strain Friedlin)
- 60s ribosomal protein l41 (4 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l22 (15 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s10 (18 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l6 (21 kDa, Protein from Leishmania major strain Friedlin)
- Cryo-em structure of leishmania major 80s ribosome snorna mutant (Complex from Leishmania major strain Friedlin)
- Lsub_rrna_chain_2 (492 kDa, RNA from Leishmania major strain Friedlin)
- Putative ribosomal protein s20 (13 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s25 (13 kDa, Protein from Leishmania major strain Friedlin)
- Sr2_chain_4 (59 kDa, RNA from Leishmania major strain Friedlin)
- 40s ribosomal protein s8 (24 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s7 (23 kDa, Protein from Leishmania major strain Friedlin)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l18a (20 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l1a (41 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s13 (17 kDa, Protein from Leishmania major strain Friedlin)
- E-site_trna_chain_s4 (6 kDa, RNA from Leishmania major strain Friedlin)
- Ribosomal protein l15 (24 kDa, Protein from Leishmania major strain Friedlin)
- El13_chain_i (24 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s3a (30 kDa, Protein from Leishmania major strain Friedlin)
- Sodium ion (22 Da, Ligand)
- 60s ribosomal protein l7a (29 kDa, Protein from Leishmania major strain Friedlin)
- Sr6_chain_6 (23 kDa, RNA from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s27-1 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l13a (25 kDa, Protein from Leishmania major strain Friedlin)
- Putative ribosomal protein l38 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal subunit protein l31 (21 kDa, Protein from Leishmania major strain Friedlin)
- Ribosomal protein l37 (9 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s15a (14 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s17 (16 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s9 (22 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein s6 (28 kDa, Protein from Leishmania major strain Friedlin)
- Ssu_rrna_chain_s1 (710 kDa, RNA from Leishmania major strain Friedlin)
- 5s_rrna_chain_8 (39 kDa, RNA from Leishmania major strain Friedlin)
- Putative ribosomal protein l3 (47 kDa, Protein from Leishmania major strain Friedlin)
- Putative 60s ribosomal protein l23 (14 kDa, Protein from Leishmania major strain Friedlin)
- 40s ribosomal protein sa (27 kDa, Protein from Leishmania major strain Friedlin)
- Putative 40s ribosomal protein s33 (9 kDa, Protein from Leishmania major strain Friedlin)
- Sr1_chain_3 (69 kDa, RNA from Leishmania major strain Friedlin)
Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6az1
Q-score: 0.566
Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G
Nat Commun (2017) 8 pp. 1589-1589 [ Pubmed: 29150609 DOI: doi:10.1038/s41467-017-01664-4 ]
- Ribosomal protein s17e (16 kDa, Protein from Leishmania donovani)
- Leishmania donovani 91s ribosome ssu (Complex from Leishmania donovani)
- Ribosomal protein s8e (25 kDa, Protein from Leishmania donovani)
- Ribosomal protein s24e (15 kDa, Protein from Leishmania donovani)
- Ribosomal protein s4 (22 kDa, Protein from Leishmania donovani)
- Ribosomal protein s19e (20 kDa, Protein from Leishmania donovani)
- Ribosomal protein s12e (15 kDa, Protein from Leishmania donovani)
- Ribosomal protein s4e (30 kDa, Protein from Leishmania donovani)
- Ribosomal protein s10e (17 kDa, Protein from Leishmania donovani)
- Ribosomal protein s19 (17 kDa, Protein from Leishmania donovani)
- Ribosomal protein s31e (17 kDa, Protein from Leishmania donovani)
- Ribosomal protein s17 (19 kDa, Protein from Leishmania donovani)
- Ribosomal protein s27e (9 kDa, Protein from Leishmania donovani)
- Ribosomal protein s2 (27 kDa, Protein from Leishmania donovani)
- Mrna (4 kDa, RNA from Leishmania donovani)
- Ribosomal protein s11 (15 kDa, Protein from Leishmania donovani)
- Paromomycin (615 Da, Ligand)
- E-site trna (24 kDa, RNA from Escherichia coli)
- Ribosomal protein s8 (14 kDa, Protein from Leishmania donovani)
- Ribosomal protein s10 (13 kDa, Protein from Leishmania donovani)
- Ribosomal protein s3 (24 kDa, Protein from Leishmania donovani)
- Ribosomal protein s28e (9 kDa, Protein from Leishmania donovani)
- Water (18 Da, Ligand)
- Ribosomal protein s1e (30 kDa, Protein from Leishmania donovani)
- Ribosomal protein s12 (15 kDa, Protein from Leishmania donovani)
- Ribosomal rna 18s (710 kDa, RNA from Leishmania donovani)
- Ribosomal protein s15 (17 kDa, Protein from Leishmania donovani)
- Ribosomal protein s7e (23 kDa, Protein from Leishmania donovani)
- Ribosomal protein s21e (16 kDa, Protein from Leishmania donovani)
- Trna-phe (24 kDa, RNA from Escherichia coli)
- Magnesium ion (24 Da, Ligand)
- Ribosomal protein s30e (7 kDa, Protein from Leishmania donovani)
- Ribosomal protein s26e (12 kDa, Protein from Leishmania donovani)
- Lack1 (34 kDa, Protein from Leishmania donovani)
- Ribosomal protein s25e (13 kDa, Protein from Leishmania donovani)
- Ribosomal protein s14 (6 kDa, Protein from Leishmania donovani)
- Ribosomal protein s5 (28 kDa, Protein from Leishmania donovani)
- Ribosomal protein s9 (16 kDa, Protein from Leishmania donovani)
- Ribosomal protein s13 (17 kDa, Protein from Leishmania donovani)
- Ribosomal protein s7 (21 kDa, Protein from Leishmania donovani)
- P-site trna (24 kDa, RNA from Escherichia coli)
- Ribosomal protein s6e (28 kDa, Protein from Leishmania donovani)