Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cgp
Q-score: 0.408
Iyer KA, Kobayashi T, Murayama T, Samso M
Structure (2025) 33 pp. 338-348.e4 [ DOI: doi:10.1016/j.str.2024.11.018 Pubmed: 39708816 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Ryr1 disease mutant y523s with fkbp12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined p1 domain (2 MDa, Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dantrolene (314 Da, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9cgq
Q-score: 0.463
Iyer KA, Kobayashi T, Murayama T, Samso M
To Be Published
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Ryr1 disease mutant y523s with fkbp12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium with refined p1 domain (2 MDa, Complex from Oryctolagus cuniculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Dantrolene (314 Da, Ligand)
Structure of RyR1 in lipid nanodisc in primed state in complex with nanobody and FKBP12
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ DOI: doi:10.1016/j.jbc.2024.107734 Pubmed: 39233227 ]
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Flubendiamide (682 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Tetraniliprole (544 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlf
Q-score: 0.375
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234 (Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlh
Q-score: 0.386
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Chimeric ryr-c4657m/g4819e ca2+/atp/caffeine/cam1234 (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8y40
Q-score: 0.306
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr-i4657m/g4819e ca2+/atp/caffeine/cam1234/chl (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of RyR1 in the primed state in the presence of pentoxifylline
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 9e18
Q-score: 0.416
To Be Published
- 3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1h-purine-2,6-dione (278 Da, Ligand)
- Calstabin-1 (Complex from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr1 and calstabin-1 (Complex)
- Ryanodine receptor 1 (Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)