Focus/local refined map in C4 of signal subtracted RyR1 particles
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8drp
Q-score: 0.514
Haji-Ghassemi O, Chen YS, Woll K, Gurrola GB, Valdivia CR, Cai W, Li S, Valdivia HH, Van Petegem F
Sci Adv (2023) 9 pp. eadf4936-eadf4936 [ DOI: doi:10.1126/sciadv.adf4936 Pubmed: 37224245 ]
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (2 MDa, Complex from Oryctolagus cuniculus)
Focus/local refined map in C1 of signal subtracted RyR1 particles in complex with ImperaCalcin
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8dtb
Q-score: 0.486
Haji-Ghassemi O, Chen YS, Woll K, Gurrola GB, Valdivia CR, Cai W, Li S, Valdivia HH, Van Petegem F
Sci Adv (2023) 9 pp. eadf4936-eadf4936 [ DOI: doi:10.1126/sciadv.adf4936 Pubmed: 37224245 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Imperacalcin (3 kDa, Protein from Pandinus imperator)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1 in complex with imperacalcin (2 MDa, Complex from Oryctolagus cuniculus)
Global map in C1 of RyR1 particles in complex with ImperaCalcin
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8duj
Q-score: 0.345
Haji-Ghassemi O, Chen YS, Woll K, Gurrola GB, Valdivia CR, Cai W, Li S, Valdivia HH, Van Petegem F
Sci Adv (2023) 9 pp. eadf4936-eadf4936 [ DOI: doi:10.1126/sciadv.adf4936 Pubmed: 37224245 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Ryr1 in complex with imperacalcin in presence of caffeine/cam1234/calcium/atp (2 MDa, Complex from Oryctolagus cuniculus)
- Imperacalcin (3 kDa, Protein from Pandinus imperator)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8dve
Q-score: 0.392
Haji-Ghassemi O, Chen YS, Woll K, Gurrola GB, Valdivia CR, Cai W, Li S, Valdivia HH, Van Petegem F
Sci Adv (2023) 9 pp. eadf4936-eadf4936 [ DOI: doi:10.1126/sciadv.adf4936 Pubmed: 37224245 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1 complex with activating ligands in open state (2 MDa, Complex)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
- Ryanodine receptor 1 (Complex from Oryctolagus cuniculus)
Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6m2w
Q-score: 0.309
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Fkbp12.6 and cam1234 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1 ca2 /atp/caffeine/cam1234/chl (2 MDa, Complex)
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (539 kDa, Protein from Oryctolagus cuniculus)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7cf9
Q-score: 0.232
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ Pubmed: 32807966 DOI: doi:10.1038/s41589-020-0627-5 ]
- Ryanodine receptor 1,ryr1 (539 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1 (Complex from Oryctolagus cuniculus)
- Fkbp1b (Complex from Homo sapiens)
- Ryr1 ca2+/chl (2 MDa, Complex)