EDS1-SAG101-NRG1A L134E heterotrimer
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 ]
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
- Eds1-sag101-nrg1a l134e heterotrimer (Complex from Arabidopsis thaliana)
- Probable disease resistance protein at5g66900 (92 kDa, Protein from Arabidopsis thaliana)
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
EDS1-SAG101-NRG1C heterotrimer
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 ]
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Probable disease resistance protein at5g66890 (47 kDa, Protein from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
- Eds1-sag101-nrg1c heterotrimer (Complex from Arabidopsis thaliana)
SIRT7-H3K36MTUnucleosome complex
Carlos MY, Babatunde E, Polina F, Esther S, Dongchun N, Henning S, Beat F
To Be Published
- Histone h2a type 2-a (13 kDa, Protein from Homo sapiens)
- Dna (149-mer) (46 kDa, DNA from Homo sapiens)
- Histone h2b type 1-j (13 kDa, Protein from Homo sapiens)
- K36 structure (Complex from Homo sapiens)
- [[(2~{r},3~{a}~{r},5~{r},6~{r},6~{a}~{r})-2-(methylamino)-6-oxidanyl-2-(propylamino)-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]oxathiol-5-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (673 Da, Ligand)
- Dna (149-mer) (45 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Nad-dependent protein deacetylase sirtuin-7 (45 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8y1v
Q-score: 0.333
To Be Published
- N-methyl-d-aspartate receptors (400 MDa, Complex from Homo sapiens)
- (2~{r},3~{s},4~{s},5~{r},6~{r})-2-(hydroxymethyl)-6-[(2~{s})-2-methyl-4-[(1~{r},2~{r},4~{s},6~{s},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s},18~{r})-7,9,13,18-tetramethyl-16-oxidanyl-5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan-6-yl]butoxy]oxane-3,4,5-triol (592 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 6 of glutamate receptor ionotropic, nmda 1 (97 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (99 kDa, Protein from Homo sapiens)
Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9crs
Q-score: 0.509
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-gamma2-beta2-alpha2 assembly
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 9crv
Q-score: 0.471
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta3-alpha1-beta2-alpha2-gamma2 assembly
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9csb
Q-score: 0.437
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9ct0
Q-score: 0.446
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta2-alpha3-gamma2 assembly
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 9ctp
Q-score: 0.391
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-3 (52 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-1 (51 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)