Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7vfv
Q-score: 0.49
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y
Cell Rep (2021) 37 pp. 109931-109931 [ DOI: doi:10.1016/j.celrep.2021.109931 Pubmed: 34731621 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Cav2.2-alpha2delta1-beta1 complex (Complex from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- (2~{s})-~{n}-[(2~{s})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide (599 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7oq4
Q-score: 0.524
Pilotto S, Fouqueau T, Lukoyanova N, Sheppard C, Lucas-Staat S, Diaz-Santin LM, Matelska D, Prangishvili D, Cheung ACM, Werner F
Nat Commun (2021) 12 pp. 5523-5523 [ DOI: doi:10.1038/s41467-021-25666-5 Pubmed: 34535646 ]
- Fe3-s4 cluster (295 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit a'' (44 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit p (5 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Conserved protein (12 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit d (29 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit h (9 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit l (10 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit k (10 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit n (7 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Rnap inhibitory protein (17 kDa, Protein from Acidianus two-tailed virus)
- Dna-directed rna polymerase subunit a' (99 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit e (20 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase subunit b (126 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Dna-directed rna polymerase, subunit f (13 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
- Complex of archaeal rna-polymerase with the atv inhibitory protein rip (421 kDa, Complex)
- Dna-directed rna polymerase, subunit g (15 kDa, Protein from Sulfolobus acidocaldarius DSM 639)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 6huk
Q-score: 0.455
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with bicuculline and megabody mb38. (330 kDa, Complex)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Megabody mb38 (Complex from Lama glama)
- Bicuculline methochloride (367 Da, Ligand)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Megabody mb38 (57 kDa, Protein from Lama glama)